, Volume 16, Issue 8, pp 2373-2374
Date: 19 May 2009

Postoperative Infectious Morbidity for Resectable Gastric Cancer—Searching Robust Predictors of Survival

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To the Editors:

Identification of prognostic markers affecting long-term survival of patients with gastric cancer is very important. Modifying these factors could lead to survival improvement. For gastric cancer, multiple factors have been reported to be associated with long-term survival. These conventional factors include tumor stage, the curative (R0) or noncurative (R1, R2) resectability, quality of surgery and extent of lymphadenectomy, age, the patient’s general status, intestinal or diffuse type according to Lauren classification and several others with a potential effect on long-term outcomes such as postoperative complications.1

However, despite a combination of most or all of these classic factors, prediction of recurrence and survival remain suboptimal and inaccurate.2 To refine prognostic prediction, recent research on genetics, gene-expression profiling studies, and personal genomics has provided exciting findings for several solid tumors, including gastric cancer.3