, Volume 16, Issue 8, pp 2369-2370
Date: 16 May 2009

Local Excision for Rectal Cancer—Safety and Efficacy Challenges

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Progress in basic science has been successfully translated into clinical practice in surgical and adjuvant treatment, improving survival of patients with solid cancers including colorectal, gastric, breast, and other tumors.13 With high survival rates for early-stage solid cancers, efforts have been focused on the improvement of quality of life (QOL).

In a recent issue of the Annals of Surgical Oncology, Borschitz et al. report on how local excision for rectal cancer could be safely performed, improving QOL without worsening oncological outcomes.4 The authors evaluate 150 patients who were treated with local excision for T1 tumors. All patients with high-risk disease in histopathological exam, namely those with pT1 (G3-4/L1/V1/R1/Rx/R ≤ mm) or pT2 tumors, were reoperated on. With this careful strategy, the recurrence rates were low. On the other hand, in high-risk patients in whom no reoperation was performed, the local recurrence rate was high and prognosis poor. The au