Outcomes of Ablation Versus Resection for Colorectal Liver Metastases: Are We Comparing Apples with Oranges?
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The incidence of colorectal cancer is approximately 150,000 new cases per year in the USA.1 Although up to 50% of patients have or will develop liver metastases, only about 20–25% of these lesions are resectable.2 Surgical resection has been the preferred treatment modality of resectable hepatic metastases. Over time, methods for local ablation have been developed with the goal of increasing the number of patients eligible for liver-directed therapy. Radiofrequency ablation (RFA) is currently the most commonly applied ablation method. RFA involves the application of an alternating electric current in the range of radiofrequency waves applied through a needle electrode placed directly in the tumor, resulting in a zone of necrosis surrounding the electrode. Specifically, as the temperature within the tissue is elevated beyond 50–60°C, proteins are denatured, cells are destroyed, and a zone of necrosis surrounding the electrode develops.3 Use of ablative approaches has been proposed both ...
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- Outcomes of Ablation Versus Resection for Colorectal Liver Metastases: Are We Comparing Apples with Oranges?
Annals of Surgical Oncology
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