Annals of Surgical Oncology

, Volume 16, Issue 5, pp 1331–1336

Decrease in Hemoglobin Levels Following Surgery Influences the Outcome in Head and Neck Cancer Patients Treated with Accelerated Postoperative Radiotherapy

  • Berrin Pehlivan
  • Abderrahim Zouhair
  • François Luthi
  • Luc Bron
  • Philippe Pasche
  • Daniela Dragusanu
  • David Azria
  • Oscar Matzinger
  • René O. Mirimanoff
  • Mahmut Ozsahin
Head and Neck Oncology

DOI: 10.1245/s10434-009-0355-2

Cite this article as:
Pehlivan, B., Zouhair, A., Luthi, F. et al. Ann Surg Oncol (2009) 16: 1331. doi:10.1245/s10434-009-0355-2

Abstract

Aim

To assess the influence of hemoglobin (Hb) levels in locally advanced head and neck cancer (LAHNC) patients treated with surgery and postoperative radiotherapy (PORT).

Material and Methods

Pre- and postoperative Hb levels were collected in 79 patients treated with surgery followed by accelerated PORT for LAHNC. Median follow-up was 52 months (range 12–95 months).

Results and Discussion

Four-year overall survival (OS) rate was 51%. Neither pre- nor postoperative Hb level (<120 or 130 g/l in women or men, respectively) influenced the outcome. However, when Hb decrease between pre- and postoperative Hb values was taken into account, 4-year OS was significantly higher in patients with Hb difference less than 38 g/l (quartile value) compared with those with Hb decrease 38 g/l or more (61% versus 16%, P = 0.008).

Conclusion

Decrease in Hb level by more than 38 g/l after surgery secondary to blood loss influences the outcome when postoperative RT is indicated.

Copyright information

© Society of Surgical Oncology 2009

Authors and Affiliations

  • Berrin Pehlivan
    • 1
  • Abderrahim Zouhair
    • 1
  • François Luthi
    • 2
  • Luc Bron
    • 3
  • Philippe Pasche
    • 3
  • Daniela Dragusanu
    • 1
  • David Azria
    • 1
  • Oscar Matzinger
    • 1
  • René O. Mirimanoff
    • 1
  • Mahmut Ozsahin
    • 1
  1. 1.Radiation OncologyUniversity Hospital Center, University of LausanneLausanneSwitzerland
  2. 2.Medical OncologyUniversity Hospital Center, University of LausanneLausanneSwitzerland
  3. 3.Otolaryngology-Head and Neck SurgeryUniversity Hospital Center, University of LausanneLausanneSwitzerland