, Volume 16, Issue 2, pp 544-545
Date: 03 Dec 2008

Predicting and Preventing Positive Surgical Margins and Local Failures in Breast-Conserving Surgery

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To the Editor

Standard treatment of early-stage breast cancer includes breast-conserving surgery (BCS).1 Despite advances with radiation and adjuvant empirical cytotoxic and targeted systemic treatment, tumor-free surgical margins continue to play an important role in preventing local recurrence, and thus it is considered essential in designing treatment strategies.2,3

Prediction of surgical margins in both first surgical resection and reexcision is a helpful tool to prevent positive margins and to select the appropriate extent of surgery. Therefore, the report by Kurniawan and colleagues for the potential prediction of surgical margins will attract the attention of surgeons.4 On the basis of a population-based breast-screening program in Melbourne, Australia, these authors evaluated clinicopathologic data on 2160 women diagnosed with ductal carcinoma-in-situ or invasive cancer and treated with BCS.

Kurniawan et al. conclude that after BCS, patients with mammographic microcalcifications, ...