Annals of Surgical Oncology

, Volume 15, Issue 12, pp 3433–3439

Preoperative Serum Carcinoembryonic Antigen Level as a Predictive Factor of Recurrence After Curative Resection of Colorectal Cancer

  • Ryo Takagawa
  • Syoichi Fujii
  • Mitsuyoshi Ohta
  • Yasuhiko Nagano
  • Chikara Kunisaki
  • Shigeru Yamagishi
  • Shunichi Osada
  • Yasushi Ichikawa
  • Hiroshi Shimada
Gastrointestinal Oncology

DOI: 10.1245/s10434-008-0168-8

Cite this article as:
Takagawa, R., Fujii, S., Ohta, M. et al. Ann Surg Oncol (2008) 15: 3433. doi:10.1245/s10434-008-0168-8

Abstract

Background

We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colorectal cancer (CRC).

Patients and Methods

The study group comprised 638 patients. The optimal cutoff value for the preoperative serum CEA level was determined. Predictive factors of recurrence were evaluated using multivariate analyses. The relapse-free time was investigated according to the CEA level.

Results

All patients underwent potentially curative resection for CRC without distant metastasis, classified as stage I, II, or III. The optimal cutoff value for preoperative serum CEA level was 10 ng/ml. Elevated preoperative serum CEA level was observed in 92 patients. Multivariate analysis identified tumor–node–metastasis (TNM) stage and preoperative serum CEA level as independent predictive factors of recurrence. The relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml significantly differed in patients with stage II and III. However, there was no significant difference in relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml in patients with stage I.

Conclusion

Preoperative serum CEA is a reliable predictive factor of recurrence after curative surgery in CRC patients and a useful indicator of the optimal treatment after resection, particularly for cases classified as stage II or stage III.

Copyright information

© Society of Surgical Oncology 2008

Authors and Affiliations

  • Ryo Takagawa
    • 1
  • Syoichi Fujii
    • 1
  • Mitsuyoshi Ohta
    • 1
  • Yasuhiko Nagano
    • 1
  • Chikara Kunisaki
    • 1
  • Shigeru Yamagishi
    • 2
  • Shunichi Osada
    • 2
  • Yasushi Ichikawa
    • 2
  • Hiroshi Shimada
    • 2
  1. 1.Department of Surgery, Gastroenterological CenterYokohama City UniversityYokohamaJapan
  2. 2.Department of Gastroenterological SurgeryYokohama City University, Graduate School of MedicineYokohamaJapan

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