Breast Oncology

Annals of Surgical Oncology

, Volume 15, Issue 12, pp 3369-3377

Lymphovascular Invasion and Lobular Histology are Associated with Increased Incidence of Isolated Tumor Cells in Sentinel Lymph Nodes from Early-Stage Breast Cancer Patients

  • Elizabeth A. MittendorfAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center
  • , Aysegul A. SahinAffiliated withDepartment of Pathology, The University of Texas M. D. Anderson Cancer Center
  • , Susan L. TuckerAffiliated withDepartment of Bioinformatics and Computational Biology, The University of Texas M. D. Anderson Cancer Center
  • , Funda Meric-BernstamAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center
  • , Min YiAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center
  • , Khazi M. NayeemuddinAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center
  • , Gildy V. BabieraAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center
  • , Merrick I. RossAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center
  • , Barry W. FeigAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center
    • , Henry M. KuererAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center
    • , Kelly K. HuntAffiliated withDepartment of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center Email author 

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Abstract

Background

Isolated tumor cells (ITC) are more likely to be identified when serial sectioning and immunohistochemical staining are used to evaluate sentinel lymph nodes (SLN). Our goal was to identify clinicopathologic features associated with ITC in patients undergoing sentinel lymph node dissection (SLND).

Methods

We reviewed clinicopathologic data for 3557 patients with no clinical evidence of lymph node metastases undergoing SLND between November 1993 and March 2007. Patients were staged according to the 6th edition of the American Joint Committee on Cancer staging system, with metastasis ≤.2 mm classified as ITC.

Results

A SLN was identified in 3475 patients (97.7%), including 2518 (72.4%) with negative nodes and 169 (4.9%) with ITC. A statistically significant association existed between lobular histology and the identification of ITC; 13.6% of patients with ITC had lobular histology versus 7.3% of patients with a negative SLN (P = .003). The presence of lymphovascular invasion (LVI) was also associated with ITC; 18.3% of patients with ITC had LVI in the primary tumor versus 8.5% of patients with a negative SLN (P < .001). No difference existed between patients with and without ITC with respect to T stage, grade, estrogen receptor, progesterone receptor, HER2/neu status, or biopsy method.

Conclusion

The association between ITC and LVI, a known predictor of poor outcome, suggests ITC may have clinical relevance. The relationship between lobular histology and ITC is consistent with the known pattern of lobular metastases, which frequently present as small foci requiring immunohistochemistry for detection. Longer follow-up is needed to determine whether ITC have prognostic significance.