Annals of Surgical Oncology

, Volume 15, Issue 4, pp 1064–1069

PIK3CA Exon 20 Mutation is Independently Associated with a Poor Prognosis in Breast Cancer Patients

  • Yuen-Liang Lai
  • Bey-Liing Mau
  • Wen-Hsuan Cheng
  • Han-Ming Chen
  • Hsi-Hsiung Chiu
  • Chin-Yuan Tzen
Breast Oncology

DOI: 10.1245/s10434-007-9751-7

Cite this article as:
Lai, YL., Mau, BL., Cheng, WH. et al. Ann Surg Oncol (2008) 15: 1064. doi:10.1245/s10434-007-9751-7

Abstract

Background

Prognostic factors that could select breast cancer patients with poor survival, and influence clinical trials of targeted therapy, are needed. However, the reported observations regarding the impact of PI3KCA mutation on breast cancers are controversial.

Methods

We analyzed exons 4, 7, 9, and 20 of PI3KCA on a series of 158 patients. Clinicopathological characteristics were correlated with the mutation data.

Results

Among 152 patients who were available for follow-up (median follow-up time, 6.57 years), 26% had PIK3CA mutations, more than half of which occurred in exon 20. The five-year survival rate of patients with exon 20 mutations (46%) was significantly lower than that of patients without (75%) (p = 0.0054). Multivariate analysis showed that PIK3CA exon 20 mutations and nodal involvement were independent risk factors for overall survival. The relative risk of death in patients with PIK3CA exon 20 mutations was 2.881 (95% CI, 1.406–5.900; p = 0.0038).

Conclusions

PIK3CA mutations are common in invasive ductal carcinomas of the breast. Our result suggests that PIK3CA exon 20 mutation is an independent risk factor for poor prognosis in breast cancer patients, indicating that differences in patient numbers with PIK3CA exon 20 mutations in study and control arms should be avoided in clinical trials of PI3K inhibitors.

Keywords

PI3K PIK3CA mutation Prognosis Breast cancer 

Copyright information

© Society of Surgical Oncology 2008

Authors and Affiliations

  • Yuen-Liang Lai
    • 1
    • 2
    • 3
  • Bey-Liing Mau
    • 4
  • Wen-Hsuan Cheng
    • 5
  • Han-Ming Chen
    • 6
  • Hsi-Hsiung Chiu
    • 7
  • Chin-Yuan Tzen
    • 5
    • 8
    • 9
  1. 1.Hospice Palliative Care CenterMackay Memorial HospitalDanshuiTaiwan
  2. 2.Center for General EducationNational Yang-Ming UniversityBeitouTaiwan
  3. 3.School of MedicineTaipei Medical UniversityXinyiTaiwan
  4. 4.Division of General Internal MedicineSun Yat-Sen Cancer CenterBeitouTaiwan
  5. 5.Department of PathologyMackay Memorial HospitalDanshuiTaiwan
  6. 6.Department of SurgeryTen-Chan General HospitalChungliTaiwan
  7. 7.Department of SurgeryCheng-Ching HospitalTaichungTaiwan
  8. 8.Mackay MedicineNursing and Management CollegeBeitouTaiwan
  9. 9.National Taipei College of NursingBeitouTaiwan

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