, Volume 15, Issue 5, pp 1538-1539
Date: 22 Dec 2007

ACE Inhibitors: A Novel Treatment for Neurofibroma

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To the Editor:

Von Recklinghausen neurofibromatosis (NF1) affects 1 in 3500 newborn children worldwide. Neurofibromas are common tumors found in neurofibromatosis type 1 (NF1) patients.1 These complex tumors are composed of Schwann cells, mast cells, fibroblasts, and perineurial cells embedded in collagen that provide a lattice for tumor invasion. Fibroblasts are a major cellular constituent in neurofibromas and are a source of collagen that constitutes ∼50% of the dry weight of the tumor. The secretion of collagen and subsequent extracellular matrix remodeling in the emerging tumor are fundamental events that provide a cellular and protein infrastructure to allow tumor invasion and the recruitment of blood vessels.2,3

Recent studies in murine models have shown that inflammatory mast cells secrete growth factors to stimulate fibroblast proliferation, collagen synthesis, and migration. This is consistent with the observation that activated mast cells secrete proinflammatory growth factors ...

Received October 26, 2007; accepted October 26, 2007; published online Month 00, 2008.
Published by Springer Science+Business Media, Inc. © 2008 The Society of Surgical Oncology, Inc.