Annals of Surgical Oncology

, Volume 15, Issue 2, pp 609–617

Prognostic Significance of the Immediate Early Response Gene X-1 (IEX-1) Expression in Pancreatic Cancer

Authors

    • Department of SurgeryKitano Hospital, Tazuke-Kofukai Medical Research Institute
  • Koichi Azuma
    • Division of Respirology, Neurology, and Rheumatology, Department of Internal MedicineKurume University School of Medicine
  • Tatsuya Hirai
    • Department of PathologyKitano Hospital, Tazuke-Kofukai Medical Research Institute
  • Hiroki Hashida
    • Department of SurgeryKitano Hospital, Tazuke-Kofukai Medical Research Institute
  • Michiyuki Kanai
    • Department of SurgeryKitano Hospital, Tazuke-Kofukai Medical Research Institute
  • Takashi Yanagawa
    • Biostatistics CenterKurume University
  • Arimichi Takabayashi
    • Department of SurgeryKitano Hospital, Tazuke-Kofukai Medical Research Institute
Hepatic and Pancreatic Tumors

DOI: 10.1245/s10434-007-9669-0

Cite this article as:
Sasada, T., Azuma, K., Hirai, T. et al. Ann Surg Oncol (2008) 15: 609. doi:10.1245/s10434-007-9669-0

Abstract

Background

The immediate early response gene X-1 (IEX-1) is a stress-inducible protein that is involved in the regulation of cell proliferation and apoptosis. The aim of this study was to evaluate the prognostic significance of IEX-1 expression in pancreatic cancer.

Methods

IEX-1 protein expression was examined on paraffin-embedded specimens from 78 patients with pancreatic ductal adenocarcinoma using immunohistochemistry. The relationships between the IEX-1 expression and other clinicopathological parameters and patient survival were evaluated. A similar analysis was conducted in a subgroup of 48 patients, who underwent a macroscopically curative resection with detailed information on the pathological findings.

Results

Among 78 pancreatic cancer patients, 41 patients (53%) were positive for IEX-1 staining. In a multivariate analysis, curative operation (P < .001), pathological stage I–III (P = .001), and positive IEX-1 expression (P = .002) were significantly favorable factors for survival. In a subgroup of 48 patients undergoing a macroscopically curative surgery, IEX-1 expression was positive in 28 patients (58%). A significant negative correlation was observed between the IEX-1 expression and serosal (P = .032) or arterial (P = .040) invasion of tumors. A multivariate analysis demonstrated limited local invasion (pT1-3, P = .021), negative lymph node involvement (pN0, P < .001), and positive IEX-1 expression (P = .004) to be significantly favorable factors for survival.

Conclusions

The positive IEX-1 expression in tumor tissues may be associated with a better prognosis in pancreatic cancer. An immunohistochemical assessment of IEX-1 expression may therefore be helpful for predicting patient prognosis in this disease.

Keywords

IEX-1Pancreatic cancerPrognosisImmunohistochemistry

Copyright information

© Society of Surgical Oncology 2007