Expression of Human Leukocyte Antigen G (HLA-G) Correlates with Poor Prognosis in Gastric Carcinoma
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
We had previously demonstrated that human leukocyte antigen G (HLA-G) was expressed in a majority of primary colorectal carcinomas and that the detection of HLA-G expression had a strong and independent prognostic value for that cancer. Currently, we investigate whether or not HLA-G is also expressed in patients with gastric carcinoma and whether the expression has any clinical application value.
The expression of HLA-G was investigated immunohistochemically in 160 patients with gastric carcinoma. The correlation between HLA-G status and various clinicopathological parameters was analyzed with the levels of HLA-G expression used to compare the survival length amongst patients.
HLA-G protein expression was observed in 71% (113 of 160) of the primary site of gastric carcinomas, but not in the normal stomach tissues. HLA-G expression in the tumors was significantly correlated with the tumor location, histological grade, depth of invasion, lymph nodal metastasis, clinical stages of the disease, and host immune response (P = .012, .008, .001, .038, .030, and .016, respectively). Patients with HLA-G positive tumors had a significantly shorter survival time than those patients with tumors that were HLA-G negative (P = .001). As well, in multivariate analysis, HLA-G demonstrated an independent prognostic factor (P = .0001, relative risk 9.08; 95% confidence interval, 3.44–24.0).
Overall, our results indicated that the expression of HLA-G is a characteristic feature of gastric carcinoma and that immunostaining by anti-HLA-G antibody may be a potentially useful prognostic indicator.
- Expression of Human Leukocyte Antigen G (HLA-G) Correlates with Poor Prognosis in Gastric Carcinoma
Annals of Surgical Oncology
Volume 14, Issue 10 , pp 2721-2729
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Human leukocyte antigen G (HLA-G)
- Gastric carcinoma
- Industry Sectors
- Author Affiliations
- 1. Chengdu Bioengineering Institute for Cancer Research, Chengdu, Sichuan, P.R. China
- 3. Core Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, 32 Yi Huan Lu Xi Er Duan, 610072, Chengdu, Sichuan, P.R. China
- 2. Department of Pathology, Sichuan Provincial People’s Hospital, Chengdu, Sichuan, P.R. China