Annals of Surgical Oncology

, Volume 14, Issue 10, pp 2721–2729

Expression of Human Leukocyte Antigen G (HLA-G) Correlates with Poor Prognosis in Gastric Carcinoma

  • Shang-mian Yie
  • Hong Yang
  • Shang-rong Ye
  • Ke Li
  • Dan-dan Dong
  • Xin-mei Lin
Gastrointestinal Oncology

DOI: 10.1245/s10434-007-9464-y

Cite this article as:
Yie, S., Yang, H., Ye, S. et al. Ann Surg Oncol (2007) 14: 2721. doi:10.1245/s10434-007-9464-y

Abstract

Objective

We had previously demonstrated that human leukocyte antigen G (HLA-G) was expressed in a majority of primary colorectal carcinomas and that the detection of HLA-G expression had a strong and independent prognostic value for that cancer. Currently, we investigate whether or not HLA-G is also expressed in patients with gastric carcinoma and whether the expression has any clinical application value.

Methods

The expression of HLA-G was investigated immunohistochemically in 160 patients with gastric carcinoma. The correlation between HLA-G status and various clinicopathological parameters was analyzed with the levels of HLA-G expression used to compare the survival length amongst patients.

Results

HLA-G protein expression was observed in 71% (113 of 160) of the primary site of gastric carcinomas, but not in the normal stomach tissues. HLA-G expression in the tumors was significantly correlated with the tumor location, histological grade, depth of invasion, lymph nodal metastasis, clinical stages of the disease, and host immune response (P= .012, .008, .001, .038, .030, and .016, respectively). Patients with HLA-G positive tumors had a significantly shorter survival time than those patients with tumors that were HLA-G negative (P = .001). As well, in multivariate analysis, HLA-G demonstrated an independent prognostic factor (P = .0001, relative risk 9.08; 95% confidence interval, 3.44–24.0).

Conclusions

Overall, our results indicated that the expression of HLA-G is a characteristic feature of gastric carcinoma and that immunostaining by anti-HLA-G antibody may be a potentially useful prognostic indicator.

Keywords

Human leukocyte antigen G (HLA-G)ImmunohistochemistryGastric carcinomaPrognosis

Copyright information

© Society of Surgical Oncology 2007

Authors and Affiliations

  • Shang-mian Yie
    • 1
    • 3
  • Hong Yang
    • 2
  • Shang-rong Ye
    • 1
  • Ke Li
    • 2
  • Dan-dan Dong
    • 2
  • Xin-mei Lin
    • 1
  1. 1.Chengdu Bioengineering Institute for Cancer ResearchChengduP.R. China
  2. 2.Department of PathologySichuan Provincial People’s HospitalChengduP.R. China
  3. 3.Core LaboratorySichuan Academy of Medical Sciences, Sichuan Provincial People’s HospitalChengduP.R. China