Annals of Surgical Oncology

, Volume 13, Issue 7, pp 999–1009

Galectin 7 (p53-Induced Gene 1): A New Prognostic Predictor of Recurrence and Survival in Stage IV Hypopharyngeal Cancer

  • Sven Saussez
  • Diana-Raluca Cucu
  • Christine Decaestecker
  • Dominique Chevalier
  • Herbert Kaltner
  • Sabine André
  • Agnes Wacreniez
  • Gérard Toubeau
  • Isabelle Camby
  • Hans-Joachim Gabius
  • Robert Kiss
Article

DOI: 10.1245/ASO.2006.08.033

Cite this article as:
Saussez, S., Cucu, D., Decaestecker, C. et al. Ann Surg Oncol (2006) 13: 999. doi:10.1245/ASO.2006.08.033

Abstract

Background

Eighty percent of hypopharyngeal squamous cell carcinoma patients have advanced stages (III and IV) of the disease, and biological markers are required to predict high-risk head and neck squamous cell carcinoma patients in need of highly aggressive treatments after surgery to improve the survival rate. We analyzed the potential prognostic value of galectin 7 in a series of 81 stage IV hypopharyngeal SCCs because galectin 7 is an emerging marker involved in the epidermal development of pluristratified epithelia and in epidermal cell migration.

Methods

The immunohistochemical expression of galectin 7 was determined on a series of 81 stage IV hypopharyngeal SCCs and was compared with that of galectins 1 and 3.

Results

High levels of galectin 7 expression were associated with rapid recurrence rates and dismal prognoses in these 81 stage IV hypopharyngeal SCCs, a feature not observed with galectin 3 and one observed weakly, if at all, with galectin 1.

Conclusions

These data suggest that the immunohistochemical determination of galectin 7 expression in the case of high-risk hypopharyngeal cancers is a meaningful tool to identify patients who should benefit from aggressive postsurgical adjuvant therapy after surgery, including not only radiotherapy, but also chemotherapy.

Keywords

Galectins 1, 3, and 7Hypopharyngeal cancerPrognosisRecurrenceImmunohistochemistry

Copyright information

© The Society of Surgical Oncology, Inc. 2006

Authors and Affiliations

  • Sven Saussez
    • 1
    • 2
  • Diana-Raluca Cucu
    • 2
  • Christine Decaestecker
    • 3
  • Dominique Chevalier
    • 4
  • Herbert Kaltner
    • 5
  • Sabine André
    • 5
  • Agnes Wacreniez
    • 6
  • Gérard Toubeau
    • 1
  • Isabelle Camby
    • 3
  • Hans-Joachim Gabius
    • 5
  • Robert Kiss
    • 3
  1. 1.Laboratory of Histology, Faculty of Medicine and PharmacyUniversity of Mons-HainautMonsBelgium
  2. 2.Laboratory of Anatomy, Faculty of Medicine and PharmacyUniversity of Mons-HainautMonsBelgium
  3. 3.Laboratory of Toxicology, Institute of PharmacyFree University of BrusselsBrusselsBelgium
  4. 4.Department of Oto-Rhino-Laryngology, Faculty of MedicineHôpital Claude Huriez–Centre Hospitalier Regional UniversitaireLilleFrance
  5. 5.Institute of Physiological Chemistry, Faculty of Veterinary MedicineLudwig-Maximilians UniversityMunichGermany
  6. 6.Department of Pathology, Faculty of MedicineHôpital Claude Huriez–Centre Hospitalier Regional UniversitaireLilleFrance