Annals of Surgical Oncology

, Volume 13, Issue 7, pp 927–932

The Prognostic Importance of Sentinel Lymph Node Biopsy in Thin Melanoma

Authors

  • Jaime M. Ranieri
    • Department of Surgery/Plastic and Reconstructive SurgeryIndiana University School of Medicine, Indiana University–Purdue University
    • Department of Surgery/Plastic and Reconstructive SurgeryIndiana University School of Medicine, Indiana University–Purdue University
  • Stacie Wenck
    • Department of Surgery/Plastic and Reconstructive SurgeryIndiana University School of Medicine, Indiana University–Purdue University
  • Cynthia S. Johnson
    • Department of Medicine/BiostatisticsIndiana University School of Medicine, Indiana University–Purdue University
  • John J. ColemanIII
    • Department of Surgery/Plastic and Reconstructive SurgeryIndiana University School of Medicine, Indiana University–Purdue University
Article

DOI: 10.1245/ASO.2006.04.023

Cite this article as:
Ranieri, J.M., Wagner, J.D., Wenck, S. et al. Ann Surg Oncol (2006) 13: 927. doi:10.1245/ASO.2006.04.023

Abstract

Background

Sentinel lymph node biopsy (SLNB) is prognostically useful in patients with cutaneous melanoma with Breslow thickness >1 mm. The objective of this study was to determine whether sentinel node histology has similar prognostic importance in patients with thin melanomas (≤1 mm).

Methods

This was a retrospective study of patients who underwent SLNB for clinically localized melanoma at Indiana University Medical Center between 1994 and 2003. SLNB results and traditional melanoma prognostic indicators were studied in univariate log-rank tests.

Results

One hundred eighty-four patients with melanomas ≤1 mm thick underwent SLNB. SLNB was tumor positive in 12 patients (6.5%). Univariate analysis of SLNB results revealed that Breslow thickness, Clark level of invasion, and mitotic index were associated with SLNB status. Tumor positivity was observed at different rates in tumor thickness subsets: <.75 mm, 2.3%; and .75 to 1.0 mm, 10.2% (P = .0372). Disease-free survival and overall survival were significantly associated with SLNB results in melanomas ≤1 mm (log-rank test: P < .0001 and P = .0125, respectively) at a median follow-up of 26.3 months.

Conclusions

SLNB histology in melanomas ≤1.0 mm deep is a significant predictor of outcome. SLNB should be considered for selected patients with melanomas .75 to 1.0 mm.

Keywords

MelanomaMetastasesSentinel lymph nodePrognosisTumor thickness Breslow level

Copyright information

© The Society of Surgical Oncology, Inc. 2006