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Hepatic Intra-Arterial Chemotherapy

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References

  1. Landis SH, Murray T, Bolden S, Wingo PA (1999) Cancer statistics. CA Cancer J Clin 49(1):8–31

    CAS  PubMed  Google Scholar 

  2. Rougier P, Laplanche A, Huguier M, et al (1992) Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: long-term results of a prospective randomized trial. J Clin Oncol 10:1112–8

    CAS  PubMed  Google Scholar 

  3. Scheele J, Stang R, Altendorf-Hofmann A, Paul M (1995) Resection of colorectal liver metastases. World J Surg 19:59–71

    Article  CAS  PubMed  Google Scholar 

  4. Wagner JS, Adson MA, Van Heerden JA, Adson MH, Ilstrup DM (1984) The natural history of hepatic metastases from colorectal cancer. A comparison with resective treatment. Ann Surg 199:502–8

    CAS  PubMed  Google Scholar 

  5. Fong Y, Cohen AM, Fortner JG, et al (1997) Liver resection for colorectal metastases. J Clin Oncol 15:938–46

    CAS  PubMed  Google Scholar 

  6. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH (1999) Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 230:309–18

    Article  CAS  PubMed  Google Scholar 

  7. Sigurdson ER, Ridge JA, Kemeny N, Daly JM. Tumor and liver drug uptake following hepatic artery and portal vein infusion. J Clin Oncol 1987;5:1836–40

    CAS  PubMed  Google Scholar 

  8. Ackerman NB (1974) The blood supply of experimental liver metastases. IV. Changes in vascularity with increasing tumor growth. Surgery 75:589–96

    CAS  PubMed  Google Scholar 

  9. Portal vein chemotherapy for colorectal cancer: a meta-analysis of 4000 patients in 10 studies. Liver Infusion Meta-Analysis Group. J Natl Cancer Inst 1997;89:497–505

  10. Ensminger WD, Rosowsky A, Raso V, et al A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2′-deoxyuridine and 5-fluorouracil. Cancer Res 1978;38(11 Pt 1):3784–92

    CAS  PubMed  Google Scholar 

  11. Sullivan RD, Zurek WZ (1965) Chemotherapy for liver cancer by protracted ambulatory infusion. JAMA 194:481–6

    Article  CAS  PubMed  Google Scholar 

  12. Cheng J, Hong D, Zhu G, Swanstrom LL, Hansen PD (2004) Laparoscopic placement of hepatic artery infusion pumps: technical considerations and early results. Ann Surg Oncol 11:589–97

    Article  PubMed  Google Scholar 

  13. Buroker T, Samson M, Correa J, Fraile R, Vaitkevicius VK (1976) Hepatic artery infusion of 5-FUDR after prior systemic 5-fluorouracil. Cancer Treat Rep 60:1277–9

    CAS  PubMed  Google Scholar 

  14. Oberfield RA, McCaffrey JA, Polio J, Clouse ME, Hamilton T (1979) Prolonged and continuous percutaneous intra-arterial hepatic infusion chemotherapy in advanced metastatic liver adenocarcinoma from colorectal primary. Cancer 44:414–23

    CAS  PubMed  Google Scholar 

  15. Patt YZ, Mavligit GM, Chuang VP, et al (1980) Percutaneous hepatic arterial infusion (HAI) of mitomycin C and floxuridine (FUDR): an effective treatment for metastatic colorectal carcinoma in the liver. Cancer 46:261–5

    CAS  PubMed  Google Scholar 

  16. Balch CM, Urist MM, Soong SJ, McGregor M (1983) A prospective phase II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump. Ann Surg 198:567–73

    CAS  PubMed  Google Scholar 

  17. Kemeny N, Daly J, Reichman B, Geller N, Botet J, Oderman P (1987) Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. A randomized trial. Ann Intern Med 107:459–65

    CAS  PubMed  Google Scholar 

  18. Chang AE, Schneider PD, Sugarbaker PH, Simpson C, Culnane M, Steinberg SM A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. Ann Surg 1987;206:685–93

    CAS  PubMed  Google Scholar 

  19. Hohn DC, Stagg RJ, Friedman MA, et al. A randomized trial of continuous intravenous versus hepatic intraarterial floxuridine in patients with colorectal cancer metastatic to the liver: the Northern California Oncology Group trial. J Clin Oncol 1989;7:1646–54

    CAS  PubMed  Google Scholar 

  20. Wagman LD, Kemeny MM, Leong L, et al (1990) A prospective, randomized evaluation of the treatment of colorectal cancer metastatic to the liver. J Clin Oncol 8:1885–93

    CAS  PubMed  Google Scholar 

  21. Martin JK Jr, O’Connell MJ, Wieand HS, et al. Intra-arterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal cancer. A randomized trial. Arch Surg 1990; 125:1022–7

    PubMed  Google Scholar 

  22. Allen-Mersh TG, Earlam S, Fordy C, Abrams K, Houghton J Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases. Lancet 1994;344:1255–60

    CAS  PubMed  Google Scholar 

  23. Grage TB, Vassilopoulos PP, Shingleton WW, et al Results of a prospective randomized study of hepatic artery infusion with 5-fluorouracil versus intravenous 5-fluorouracil in patients with hepatic metastases from colorectal cancer: a Central Oncology Group study. Surgery 1979;86:550–5

    CAS  PubMed  Google Scholar 

  24. Kerr DJ, McArdle CS, Ledermann J, et al (2003) Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases: a multicentre randomised trial. Lancet 361:368–73

    CAS  PubMed  Google Scholar 

  25. Lorenz M, Muller HH, Schramm H, et al (1998) Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. German Cooperative on Liver Metastases (Arbeitsgruppe Lebermetastasen). Ann Surg 228:756–62

    Article  CAS  PubMed  Google Scholar 

  26. Harmantas A, Rotstein LE, Langer B (1996) Regional versus systemic chemotherapy in the treatment of colorectal carcinoma metastatic to the liver. Is there a survival difference? Meta-analysis of the published literature. Cancer 78:1639–45

    Article  CAS  PubMed  Google Scholar 

  27. Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer. Meta-Analysis Group in Cancer. J Natl Cancer Inst 1996;88: 252–8

  28. Durand-Zaleski I, Roche B, Buyse M, et al (1997) Economic implications of hepatic arterial infusion chemotherapy in treatment of nonresectable colorectal liver metastases. Meta-Analysis Group in Cancer. J Natl Cancer Inst 89:790–5

    Article  CAS  PubMed  Google Scholar 

  29. de Gramont A, Figer A, Seymour M, et al (2000) Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18:2938–47

    PubMed  Google Scholar 

  30. Giacchetti S, Perpoint B, Zidani R, et al (2000) Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 18:136–47

    CAS  PubMed  Google Scholar 

  31. Blair SL, Grant M, Chu DZ, et al (2003) Quality of life in patients with colorectal metastasis and intrahepatic chemotherapy. Ann Surg Oncol 10:144–9

    Article  PubMed  Google Scholar 

  32. Rosen CB, Nagorney DM, Taswell HF, et al (1992) Perioperative blood transfusion and determinants of survival after liver resection for metastatic colorectal carcinoma. Ann Surg 216:493–504

    CAS  PubMed  Google Scholar 

  33. Tono T, Hasuike Y, Ohzato H, Takatsuka Y, Kikkawa N (2000) Limited but definite efficacy of prophylactic hepatic arterial infusion chemotherapy after curative resection of colorectal liver metastases: a randomized study. Cancer 88:1549–56

    Article  CAS  PubMed  Google Scholar 

  34. Kemeny MM, Adak S, Gray B, et al (2002) Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy—an intergroup study. J Clin Oncol 20:1499–505

    Article  PubMed  Google Scholar 

  35. Kemeny N, Huang Y, Cohen AM, et al (1999) Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 341:2039–48

    Article  CAS  PubMed  Google Scholar 

  36. Rudroff C, Altendorf-Hoffmann A, Stangl R, Scheele J (1999) Prospective randomised trial on adjuvant hepatic-artery infusion chemotherapy after R0 resection of colorectal liver metastases. Langenbecks Arch Surg 384:243–9

    Article  CAS  PubMed  Google Scholar 

  37. Nelson R, Freels S. Hepatic artery adjuvant chemotherapy for patients having resection or ablation of colorectal cancer metastatic to the liver. Cochrane Database Syst Rev 2004; CD003770

  38. Sadahiro S, Suzuki T, Ishikawa K, et al (2004) Prophylactic hepatic arterial infusion chemotherapy for the prevention of liver metastasis in patients with colon carcinoma: a randomized control trial. Cancer 100:590–7

    Article  CAS  PubMed  Google Scholar 

  39. Weiss L, Grundmann E, Torhorst J, et al (1986) Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol 150:195–203

    Article  CAS  PubMed  Google Scholar 

  40. Espat NJ (2004) A potential role for perioperative hepatic arterial infusion chemotherapy? Cancer 100:437–40

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, University of Illinois at Chicago, M/C 958, 840 S. Wood Street, Room 435E, Chicago, Illinois, 60612

    Evan S. Ong MD, Madeleine Poirier MDCM, MSc, FRCS(C) & N. Joseph Espat MD, MS, FACS

Authors
  1. Evan S. Ong MD
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  2. Madeleine Poirier MDCM, MSc, FRCS(C)
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  3. N. Joseph Espat MD, MS, FACS
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Correspondence to N. Joseph Espat MD, MS, FACS.

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Ong, E.S., Poirier, M. & Espat, N.J. Hepatic Intra-Arterial Chemotherapy. Ann Surg Oncol 13, 142–149 (2006). https://doi.org/10.1245/ASO.2006.01.005

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  • DOI: https://doi.org/10.1245/ASO.2006.01.005

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