Annals of Surgical Oncology

, Volume 12, Issue 4, pp 273–281

RON, a Tyrosine Kinase Receptor Involved in Tumor Progression and Metastasis

  • E. Ramsay Camp
  • Wenbiao Liu
  • Fan Fan
  • Anthony Yang
  • Ray Somcio
  • Lee M. Ellis
Educational Review

DOI: 10.1245/ASO.2005.08.013

Cite this article as:
Camp, E.R., Liu, W., Fan, F. et al. Ann Surg Oncol (2005) 12: 273. doi:10.1245/ASO.2005.08.013

Abstract

Tyrosine kinase receptors mediate many critical cellular functions that contribute to tumor progression and metastasis and thus are potential targets for molecular-based cancer therapy. As has been found for many receptor tyrosine kinases, RON (recepteur d’origine nantais) and its ligand, macrophage-stimulating protein, have recently been implicated in the progression and metastasis of tumors. In in vitro experiments using colon and breast cancer cell lines, overexpression of RON led to increased invasion and migration of cancer cells and prevented apoptosis and anoikis. In addition, transgenic mice engineered to overexpress RON in the lung epithelium developed multiple pulmonary tumors, suggesting a role for RON in tumorigenesis. In human cancer specimens, increased RON expression has been demonstrated in colon, breast, ovarian, and lung tumors. Therefore, therapies designed to inhibit RON activation may hinder critical tumor survival mechanisms and play a role in the treatment of advanced disease.

Keywords

RON Macrophage-stimulating protein Cancer Tyrosine kinase receptor 

Copyright information

© The Society of Surgical Oncology, Inc. 2005

Authors and Affiliations

  • E. Ramsay Camp
    • 1
  • Wenbiao Liu
    • 2
  • Fan Fan
    • 2
  • Anthony Yang
    • 1
  • Ray Somcio
    • 2
  • Lee M. Ellis
    • 1
    • 2
  1. 1.Department of Surgical OncologyThe University of Texas M. D. Anderson Cancer CenterHouston
  2. 2.Department of Cancer BiologyThe University of Texas M. D. Anderson Cancer CenterHouston