Annals of Surgical Oncology

, Volume 11, Issue 2, pp 157–164

Survival and Recurrence After Breast Cancer in BRCA1/2 Mutation Carriers

  • Mahmoud El-Tamer
  • Donna Russo
  • Andrea Troxel
  • Lourdes P. Bernardino
  • Robert Mazziotta
  • Alison Estabrook
  • Beth-Ann Ditkoff
  • Freya Schnabel
  • Mahesh Mansukhani
Original Articles

DOI: 10.1245/ASO.2004.05.018

Cite this article as:
El-Tamer, M., Russo, D., Troxel, A. et al. Ann Surg Oncol (2004) 11: 157. doi:10.1245/ASO.2004.05.018

Abstract

Background: Genetic mutation is responsible for approximately 10% of breast cancers. The purpose of this study was to compare breast cancer survival and recurrence rates between BRCA1/2 mutation carriers and noncarriers.

Methods: Using the Columbia Presbyterian breast cancer database, we collected the tissue blocks of all patients younger than 65 years of age and of Jewish descent. The patients were contacted and the data updated. DNA was extracted from the tissue blocks and tested for the common mutations. The results of the genetic mutation and updated database were anonymized and merged. The survival and recurrence rates were compared between mutation carriers and noncarriers.

Results: A total of 739 breast cancer cases in 715 patients were identified. We were able to test 487 patients. We identified 30 BRCA1 and 21 BRCA2 mutation carriers, for an incidence of 10.36%. The median follow-up for the patients tested was 50 months. BRCA1 patients more frequently had estrogen- and progesterone-negative tumors and had a higher incidence of positive nodes. BRCA1 patients received chemotherapy more frequently. The incidence of in situ disease was similar for mutation and non–mutation carriers. BRCA1/2 mutation carriers had a higher incidence of bilateral disease. There was no difference in 5- or 10-year overall and breast cancer–specific survival between mutation and non–mutation carriers.

Conclusions: Breast cancer patients with BRCA1/2 mutations have a similar outcome as non–mutation carriers.

Key Words

Breast cancerGene mutationSurvivalRecurrence

Copyright information

© The Society of Surgical Oncology, Inc. 2004

Authors and Affiliations

  • Mahmoud El-Tamer
    • 1
    • 5
  • Donna Russo
    • 1
  • Andrea Troxel
    • 3
  • Lourdes P. Bernardino
    • 2
  • Robert Mazziotta
    • 2
  • Alison Estabrook
    • 4
  • Beth-Ann Ditkoff
    • 1
  • Freya Schnabel
    • 1
  • Mahesh Mansukhani
    • 2
  1. 1.Departments of Breast SurgeryColumbia-Presbyterian Comprehensive Breast CenterNew York
  2. 2.Departments of PathologyColumbia-Presbyterian Comprehensive Breast CenterNew York
  3. 3.Departments of BiostatisticsColumbia-Presbyterian Comprehensive Breast CenterNew York
  4. 4.Departments of Clinical SurgeryColumbia-Presbyterian Comprehensive Breast CenterNew York
  5. 5.Columbia-Presbyterian Hospital-Breast CenterNew York