The Prognosis of T3N0 Colon Cancer Is Dependent on the Number of Lymph Nodes Examined
- Richard S. SwansonAffiliated withNational Cancer Data Base, American College of SurgeonsDepartment of Surgery, Brigham and Women’ HospitalDivision of Surgical Oncology, Brigham and Women’ Hospital Email author
- , Carolyn C. ComptonAffiliated withNational Cancer Data Base, American College of SurgeonsDepartment of Pathology, McGill University
- , Andrew K. StewartAffiliated withNational Cancer Data Base, American College of SurgeonsAmerican College of Surgeons
- , Kirby I. BlandAffiliated withNational Cancer Data Base, American College of SurgeonsDepartment of Surgery, University of Alabama
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Background: T3N0 colon cancer is the target of many adjuvant studies. Very few studies have examined the relationship of the number of lymph nodes examined to the prognosis of this stage. We examined data from the National Cancer Data Base (NCDB) to determine whether the number of examined lymph nodes is prognostic for T3N0 colon cancer.
Methods: A total of 35,787 prospectively collected cases of T3N0 colon cancer that were surgically treated and pathologically reported from 1985 to 1991 to the NCDB as T3N0M0 were analyzed.
Results: The 5-year relative survival rate for T3N0M0 colon cancer varied from 64% if 1 or 2 lymph nodes were examined to 86% if >25 lymph nodes were examined. Three strata of lymph nodes (1–7, 8–12, and ≥13) distinguished significantly different observed 5-year survival rates.
Conclusions: These results demonstrate that the prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. A minimum of 13 lymph nodes should be examined to label a T3 colon cancer as node negative. These data suggest that adjuvant trials for T3N0 colon cancer should stratify according to the number of lymph nodes examined.
Key WordsColon cancer T3N0 Lymph nodes Prognosis
- The Prognosis of T3N0 Colon Cancer Is Dependent on the Number of Lymph Nodes Examined
Annals of Surgical Oncology
Volume 10, Issue 1 , pp 65-71
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- Colon cancer
- Lymph nodes
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- Author Affiliations
- 1. National Cancer Data Base, American College of Surgeons, Chicago, Illinois
- 2. Department of Surgery, Brigham and Women’ Hospital, Boston, Massachusetts
- 6. Division of Surgical Oncology, Brigham and Women’ Hospital, 75 Francis St., Boston, MA 02115
- 3. Department of Pathology, McGill University, Montreal, Canada
- 4. American College of Surgeons, Chicago, Illinois
- 5. Department of Surgery, University of Alabama, Birmingham, Alabama