Intraperitoneal Chemohyperthermia Using a Closed Abdominal Procedure and Cytoreductive Surgery for the Treatment of Peritoneal Carcinomatosis: Morbidity and Mortality Analysis of 216 Consecutive Procedures
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Background: Peritoneal carcinomatosis has been regarded as a lethal clinical entity. Recently, aggressive treatments combining intraperitoneal chemohyperthermia (IPCH) with cytoreductive surgery have resulted in long-term survival in selected patients. The aim of this trial was to analyze the mortality and morbidity of 216 consecutive treatments of peritoneal carcinomatosis by IPCH by using a closed abdominal procedure combined with cytoreductive surgery.
Methods: Between February 1989 and August 2001, 207 patients who underwent 216 IPCH procedures using a closed abdominal procedure with mitomycin C, cisplatin, or both were prospectively studied.
Results: The postoperative mortality and morbidity rates were 3.2% and 24.5%, respectively. The most frequent complications were digestive fistula (6.5%) and hematological toxicity (4.6%). Morbidity was statistically linked with the carcinomatosis stage (P = .016), the duration of surgery (P = .005), and the number of resections and peritonectomy procedures (P = .042). Duration of surgery and carcinomatosis stage were the most common predictors of morbidity.
Conclusions: The frequency of complications after IPCH and cytoreductive surgery was mainly associated with the carcinomatosis stage and the extent of the surgical procedure. The IPCH closed abdominal procedure has shown an acceptable frequency of adverse events.
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- Intraperitoneal Chemohyperthermia Using a Closed Abdominal Procedure and Cytoreductive Surgery for the Treatment of Peritoneal Carcinomatosis: Morbidity and Mortality Analysis of 216 Consecutive Procedures
Annals of Surgical Oncology
Volume 10, Issue 8 , pp 863-869
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Cytoreductive surgery
- Intraperitoneal chemotherapy
- Industry Sectors
- Author Affiliations
- 1. Department of Surgery, Centre Hospitalier Lyon-Sud, Pierre Bénite Cédex, France
- 5. Oncologic Hyperthermia Laboratory-Equipe Accueil “Ciblage Thérapeutique en Oncologie”, Université Claude Bernard Lyon-1, Oullins, France
- 6. Bio-Statistical Unit, Centre Jean Perrin, Clermont-Ferrand, France
- 2. Department of Oncology, Centre Hospitalier Lyon-Sud, Pierre Bénite Cédex, France
- 4. Department of Pathology, Centre Hospitalier Lyon-Sud, Pierre Bénite Cédex, France
- 3. Department of Anaesthesiology, Centre Hospitalier Lyon-Sud, Pierre Bénite Cédex, France
- 7. Surgical Department, Centre Hospitalo-Universitaire Lyon Sud, 69495, Pierre Bénite Cedex, France