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Thermal Ablation Versus Repeated Hepatic Resection for Recurrent Intrahepatic Cholangiocarcinoma

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Repeated hepatic resection (HR) and thermal ablation therapy (TAT) are increasingly being used to treat recurrent intrahepatic cholangiocarcinoma (RICC). This study compared the efficacy and safety of these procedures for RICC treatment.

Methods

Patients were studied retrospectively after curative resection of RICCs by repeated HR (n = 32) or TAT (n = 77). Treatment effectiveness and prognosis were compared between the two treatment groups.

Results

The repeated HR and TAT groups did not differ in their overall survival (OS; p = 0.996) or disease-free survival (DFS; p = 0.692) rates. However, among patients with recurrent tumors >3 cm in diameter, patients in the repeated HR group had a higher OS rate than patients in the TAT group (p = 0.037). The number of recurrent tumors and the recurrence interval were significant prognostic factors for OS. The major complications incidence rate was greater in the repeated HR group than in the TAT group (p < 0.001).

Conclusions

Repeated HR and TAT are both effective treatments for RICC with similar overall efficacies. TAT should be preferred in any cases when the RICC is ≤3 cm in diameter and technically feasible. However, for large tumors (>3 cm), repeated HR may be a better choice.

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Disclosure

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Minimal Invasion Therapy Department 1, Eastern Hepatobiliary Surgery Hospital, Shanghai, China

    Shao-Jun Zhang MD, Peng Hu MD, Neng Wang MD, Qiang Shen MD, Ai-Xue Sun MD & Guo-Jun Qian MD, PhD

  2. Division of Interventional Ultrasound, Department of Hepatobiliary Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

    Ming Kuang MD, PhD

Authors
  1. Shao-Jun Zhang MD
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  2. Peng Hu MD
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  3. Neng Wang MD
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  4. Qiang Shen MD
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  5. Ai-Xue Sun MD
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  6. Ming Kuang MD, PhD
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  7. Guo-Jun Qian MD, PhD
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Corresponding authors

Correspondence to Ming Kuang MD, PhD or Guo-Jun Qian MD, PhD.

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Zhang, SJ., Hu, P., Wang, N. et al. Thermal Ablation Versus Repeated Hepatic Resection for Recurrent Intrahepatic Cholangiocarcinoma. Ann Surg Oncol 20, 3596–3602 (2013). https://doi.org/10.1245/s10434-013-3035-1

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  • DOI: https://doi.org/10.1245/s10434-013-3035-1

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