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Development and Evaluation of Ca+ 2 Ion Cross-Linked Carboxymethyl Xanthan Gum Tablet Prepared by Wet Granulation Technique

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Abstract

The objective of this work was to study the release behavior of prednisolone from calcium-cross-linked carboxymethyl xanthan gum (CMXG) tablets in dissolution medium having different pH values prevailing in the gastrointestinal lumen. Xanthan gum (XG) was derivatized to CMXG which was then cross-linked in situ with Ca+2 ion during wet massing step of tablet preparation. Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry studies did not show any drug-polymer interaction although the drug underwent solid-state transformation during compression as evident from X-ray diffraction analysis. In vitro release study demonstrated that increase in the amount of Ca+2 ion decreased the drug release, and beyond a certain amount, the drug release increased. While increase in both drug load and tablet crushing strength decreased the drug release, increase in exposure time in acid solution of pH 1.2 increased the overall release of the drug. The mechanism of drug release was non-Fickian/anomalous. The results indicated that variation in the amount of Ca+2 ion can modulate the drug release from CMXG matrix tablets as needed.

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REFERENCES

  1. Rana V, Rai P, Tiwary AK, Singh RS, Kennedy JF, Knill CJ. Modified gums: approaches and applications in drug delivery. Carbohydr Polym. 2011;83:1031–47.

    Article  CAS  Google Scholar 

  2. Prabaharan M. Prospective of guar gum and its derivatives as controlled drug delivery systems. Int J Biol Macromol. 2011;49:117–24.

    Article  CAS  PubMed  Google Scholar 

  3. Prajapati VD, Jani GK, Moradiya NG, Randeria NP. Pharmaceutical applications of various natural gums, mucilages and their modified forms. Carbohydr Polym. 2013;92:1685–99.

    Article  CAS  PubMed  Google Scholar 

  4. Mandal S, Basu SK, Sa B. Sustained release of a water-soluble drug from alginate matrix tablets prepared by wet granulation method. AAPS PharmSciTech. 2009;10:1348–56.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Mandal S, Basu SK, Sa B. Ca2+ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride. Carbohydr Polym. 2010;82:867–73.

    Article  CAS  Google Scholar 

  6. Thimma RT, Tammishetti S. Barium chloride crosslinked carboxymethyl guar gum beads for gastrointestinal drug delivery. J Appl Polym Sci. 2001;82:3084–90.

    Article  CAS  Google Scholar 

  7. Toti US, Aminabhavi TM. Modified guar gum matrix tablet for controlled release of diltiazem hydrochloride. J Control Release. 2004;95:567–77.

    Article  CAS  PubMed  Google Scholar 

  8. Bharaniraja B, Jayaram Kumar K, Prasad CM, Sen AK. Modified katira gum for colon targeted drug delivery. J Appl Polym Sci. 2011;119:2644–51.

    Article  CAS  Google Scholar 

  9. Pal S, Sen G, Mishra S, Dey RK, Jha U. Carboxymethyl tamarind: synthesis, characterization and its application as novel drug-delivery agent. J Appl Polym Sci. 2008;110:392–400.

    Article  CAS  Google Scholar 

  10. Sungthongjeen S, Sriamornsak P, Pitaksuteepong T, Somsiri A, Puttipipatkhachorn S. Effect of degree of esterification of pectin and calcium amount on drug release from pectin-based matrix tablets. AAPS PharmSciTech. 2004;5:50–7.

    Article  PubMed Central  Google Scholar 

  11. Wei X, Sun N, Wu B, Yin C, Wu W. Sigmoidal release of indomethacin from pectin matrix tablets: effect of in situ crosslinking by calcium cations. Int J Pharm. 2006;318:132–8.

    Article  CAS  PubMed  Google Scholar 

  12. Sinha VR, Kumria R. Polysaccharide matrices for microbially triggered drug delivery to the colon. Drug Dev Ind Pharm. 2004;30:143–50.

    Article  CAS  PubMed  Google Scholar 

  13. Al-Saidan SM, Krishnaiah YSR, Patro S, Satyanaryana V. In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride. AAPS PharmSciTech. 2005;6:E14–21.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Vendruscolo CW, Andreazza IF, Ganter JLMS, Ferrero C, Bresolin TMB. Xanthan and galactomannan (from M. scabrella) matrix tablets for oral controlled delivery of theophylline. Int J Pharm. 2005;296:1–11.

    Article  CAS  PubMed  Google Scholar 

  15. Mughal MA, Iqbal Z, Neau SH. Guar gum, xanthan gum, and HPMC can define release mechanisms and sustain release of propranolol hydrochloride. AAPS PharmSciTech. 2011;12:77–87.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Sa B, Setty CM. Novel gel microbeads based on natural polysaccharides. Indian Patent No. 224992, 2008.

  17. Indian Pharmacopoeia Commission. Indian Pharmacopoeia, volume I. Ghaziabad, India: Indian Pharmacopoeia Commission; 2010.

  18. Agnihotri SA, Aminabhavi TM. Novel interpenetrating network chitosan- poly (ethylene oxide-g-acrylamide) hydrogel microspheres for the controlled release of capecitabine. Int J Pharm. 2006;324:103–15.

    Article  CAS  PubMed  Google Scholar 

  19. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983;15:25–35.

    Article  CAS  Google Scholar 

  20. Ritger PL, Peppas NA. A simple euation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release. 1987;5:37–42.

    Article  CAS  Google Scholar 

  21. Sujja-areevath J, Munday DL, Cox PJ, Khan KA. Release characteristics of diclofenac sodium from encapsulated natural gum mini-matrix formulation. Int J Pharm. 1996;139:53–62.

    Article  CAS  Google Scholar 

  22. Möckel JE, Lippold BC. Zero-order drug release from hydrocolloid matrices. Pharm Res. 1993;10:1066–70.

    Article  PubMed  Google Scholar 

  23. Talukdar MM, Kinget R. Swelling and drug release behaviour of xanthan gum matrix tablets. Int J Pharm. 1995;120:63–72.

    Article  CAS  Google Scholar 

  24. Baumgartner S, Pavli M, Kristl J. Effect of calcium ions on the gelling and drug release characteristics of xanthan matrix tablets. Eur J Pharm Biopharm. 2008;69:698–707.

    Article  CAS  PubMed  Google Scholar 

  25. Coviello T, Matricardi P, Marianecci C, Alhaique F. Polysaccharide hydrogels for modified release formulations. J Control Release. 2007;119:5–24.

    Article  CAS  PubMed  Google Scholar 

  26. Moresi M, Bruno M. Characterization of alginate gels using quasi-static and dynamic methods. J Food Eng. 2007;82:298–309.

    Article  CAS  Google Scholar 

  27. Reddy T, Tammishetti S. Gastric resistant microbeads of metal ion cross-linked carboxymethyl guar gum for oral drug delivery. J Microencapsulation. 2002;19:311–8.

    Article  CAS  PubMed  Google Scholar 

  28. Maestrelli F, Cirri M, Corti G, Mennini N, Mura P. Development of enteric coated calcium pectinate microspheres intended for colonic delivery. Eur J Pharm Biopharm. 2008;69:508–18.

    Article  CAS  PubMed  Google Scholar 

  29. Collett J, Moreton C. Modified-release peroral dosage forms. In: Aulton ME, editor. Pharmaceutics: the science of dosage form design. London: Churchill Livingstone; 2002. p. 289–305.

    Google Scholar 

  30. Kim CJ, Lee PI. Composite poly (vinyl alcohol) beads for controlled drug delivery. Pharm Res. 1992;9:10–6.

    Article  CAS  PubMed  Google Scholar 

  31. Ashford M, Fell J, Attwood D, Sharma H, Woodhead P. Studies on pectin formulations for colonic drug delivery. J Control Release. 1994;30:225–32.

    Article  CAS  Google Scholar 

  32. Liew CV, Chan LW, Ching AL, Heng PWS. Evaluation of sodium alginate as drug release modifier in matrix tablets. Int J Pharm. 2006;309:25–37.

    Article  CAS  PubMed  Google Scholar 

  33. Sujja-areevath J, Munday DL, Cox PJ, Khan KA. Relationship between swelling, erosion and drug release in hydrophillic natural gum mini-matrix formulations. Eur J Pharm Sci. 1998;6:207–17.

    Article  CAS  PubMed  Google Scholar 

  34. Soppimath KS, Kulkarni AR, Aminabhavi TM. Controlled release of antihypertensive drug from the interpenetrating network poly (vinyl alcohol)-guar gum hydrogel microspheres. J Biomater Sci Polym Ed. 2000;11:27–43.

    Article  CAS  PubMed  Google Scholar 

  35. Rokhade AP, Agnihotri SA, Patil SA, Mallikarjuna NN, Kulkarni PV, Aminabhavi TM. Semi-interpenetrating polymer network microspheres of gelatin and sodium carboxymethyl cellulose for controlled release of ketorolac tromethamine. Carbohydr Polym. 2006;65:243–52.

    Article  CAS  Google Scholar 

  36. Roy A, Bajpai AK, Bajpai J. Designing swellable beads of alginate and gelatin for controlled release of pesticide (cypermethrin). J Macromol Sci Pure Appl Chem. 2009;46:847–59.

    Article  CAS  Google Scholar 

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ACKNOWLEDGMENTS

One of the authors (S. Maity) wishes to express thanks to the Council of Scientific and Industrial Research, New Delhi, India, for the financial support as CSIR-SRF [Grant No. 9/96 (0727)2K12/EMR-1]. The authors also offer thanks to the Department of Science and Technology, New Delhi, India, for partial financial support under DST-PURSE program.

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  1. Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India

    Siddhartha Maity & Biswanath Sa

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  1. Siddhartha Maity
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  2. Biswanath Sa
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Correspondence to Biswanath Sa.

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Maity, S., Sa, B. Development and Evaluation of Ca+ 2 Ion Cross-Linked Carboxymethyl Xanthan Gum Tablet Prepared by Wet Granulation Technique . AAPS PharmSciTech 15, 920–927 (2014). https://doi.org/10.1208/s12249-014-0123-x

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