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Nano-extrusion: a One-Step Process for Manufacturing of Solid Nanoparticle Formulations Directly from the Liquid Phase

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Abstract

This paper presents a novel one-step process for converting a liquid stabilized nano-suspension into a solid formulation via hot-melt extrusion combined with an internal devolatilization process (nano-extrusion, NANEX). A polymer (Soluplus®) was fed into the extruder and molten, after which a stable nano-suspension was added via side-feeding devices. The solvent (water) was removed by devolatilization and the polymer solidified at the outlet. The solid material can be tableted or filled in a capsule directly. The results showed that the obtained extrudates comprised nanocrystals in the de-aggregated form, confirming that a solid nano-formulation was prepared. This method is capable of overcoming many of the problems associated with other processes involving solid nano-dosage forms and poses a straightforward approach towards manufacturing such products.

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Authors and Affiliations

  1. Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria

    Johannes Khinast

  2. Research Center Pharmaceutical Engineering, Graz, Austria

    Johannes Khinast, Ramona Baumgartner & Eva Roblegg

  3. Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens University Graz, Humboldtstrasse 46, 8010, Graz, Austria

    Eva Roblegg

Authors
  1. Johannes Khinast
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  2. Ramona Baumgartner
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  3. Eva Roblegg
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Correspondence to Eva Roblegg.

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Khinast, J., Baumgartner, R. & Roblegg, E. Nano-extrusion: a One-Step Process for Manufacturing of Solid Nanoparticle Formulations Directly from the Liquid Phase. AAPS PharmSciTech 14, 601–604 (2013). https://doi.org/10.1208/s12249-013-9946-0

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  • DOI: https://doi.org/10.1208/s12249-013-9946-0

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