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Evaluation of Meloxicam-Loaded Cationic Transfersomes as Transdermal Drug Delivery Carriers

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Abstract

The aim of this study is to develop meloxicam (MX)-loaded cationic transfersomes as skin delivery carriers and to investigate the influence of formulation factors such as cholesterol and cationic surfactants on the physicochemical properties of transfersomes (i.e., particle size, size distribution, droplet surface charge and morphology), entrapment efficiency, stability of formulations and in vitro skin permeation of MX. The transfersomes displayed a spherical structure. Their size, charge, and entrapment efficiency depended on the composition of cholesterol and cationic surfactants in the formulation. Transfersomes provided greater MX skin permeation than conventional liposomes and MX suspensions. The penetration-enhancing mechanism of skin permeation by the vesicles prepared in this study may be due to the vesicle adsorption to and/or fusion with the stratum corneum. Our results suggest that cationic transfersomes may be promising dermal delivery carriers of MX.

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Acknowledgments

The authors wish to thank the Silpakorn University Research and Development Institute, Graduate School of Silpakorn University and the Thailand Research Funds through the Golden Jubilee Ph.D. Program (Grant No. PHD/0141/2550) for financial support.

Declaration of Interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Faculty of Pharmacy, Silpakorn University, Sanamchan Palace campus, Nakhon Pathom, 73000, Thailand

    Sureewan Duangjit, Praneet Opanasopit, Theerasak Rojanarata & Tanasait Ngawhirunpat

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  1. Sureewan Duangjit
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  2. Praneet Opanasopit
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  3. Theerasak Rojanarata
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  4. Tanasait Ngawhirunpat
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Correspondence to Tanasait Ngawhirunpat.

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Duangjit, S., Opanasopit, P., Rojanarata, T. et al. Evaluation of Meloxicam-Loaded Cationic Transfersomes as Transdermal Drug Delivery Carriers. AAPS PharmSciTech 14, 133–140 (2013). https://doi.org/10.1208/s12249-012-9904-2

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  • DOI: https://doi.org/10.1208/s12249-012-9904-2

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