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Solid-State Properties of the Cyclooxygenase-1-Selective Inhibitor, SC-560

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References

  1. Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S et al. Synthesis and biological evaluation of the 1, 5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 h-pyrazol-1-yl]benzenesulfonamide (sc-58635, celecoxib). J Med Chem. 1997;40:1347–65.

    Article  CAS  PubMed  Google Scholar 

  2. Choi SH, Langenbach R, Bosetti F. Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J. 2008;22:1491–501.

    Article  CAS  PubMed  Google Scholar 

  3. Teng XW, Abu-Mellal AKM, Davies NM. Formulation dependent pharmacokinetics, bioavailability and renal toxicity of a selective cyclooxygenase-1 inhibitor SC-560 in the rat. J Pharm Pharm Sci. 2003;6:205–10.

    CAS  PubMed  Google Scholar 

  4. Long S, Theiss KL, Li T, Loftin CD. Cyclooxygenase-1-selective inhibitor sc-560. Acta Cryst. 2009;E65:o360.

    CAS  Google Scholar 

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Acknowledgment

We are thankful for the financial support by NSF (DMR-0449633).

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Room 514, Lexington, Kentucky, 40536-0082, USA

    Sihui Long, Kathryn L. Theiss, Alessandra Mattei, Charles D. Loftin & Tonglei Li

Authors
  1. Sihui Long
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  2. Kathryn L. Theiss
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  3. Alessandra Mattei
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  4. Charles D. Loftin
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  5. Tonglei Li
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Correspondence to Tonglei Li.

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Long, S., Theiss, K.L., Mattei, A. et al. Solid-State Properties of the Cyclooxygenase-1-Selective Inhibitor, SC-560. AAPS PharmSciTech 11, 485–488 (2010). https://doi.org/10.1208/s12249-010-9407-y

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  • DOI: https://doi.org/10.1208/s12249-010-9407-y

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