Abstract
Considering the diversity in physiology between species and the numerous dosage forms that exist in veterinary drug products, there are numerous complex issues that arise from the development and regulation of veterinary drugs for food-producing and companion animals. Generic drugs are no exception. The main objective of this article is to illustrate the current important similarities and differences between international veterinary bioequivalence guidelines. It is concluded that since important differences are found, these may lead to barriers in international data exchange and scientific confusion, hence fostering the need for a harmonization effort in developing consistent guidelines based on sound pharmacological and statistical principles for the approval of veterinary generic drugs around the world.
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Acknowledgments
The author would like to acknowledge the invaluable contribution of several regulatory agents for ensuring the accuracy of their country's tables and for their editorial help. As well, this author would also like to thank the following people for their editorial contribution: Drs. Erik De Ridder, Robert P. Hunter and Bill Zollers.
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Lainesse, C. International Veterinary Bioequivalence Guideline Similarities and Differences Between Australia, Canada, Europe, Japan, New Zealand and the United States. AAPS J 14, 792–798 (2012). https://doi.org/10.1208/s12248-012-9393-y
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DOI: https://doi.org/10.1208/s12248-012-9393-y