AAPS PharmSciTech

, Volume 12, Issue 2, pp 593–603

3D Simulation of Internal Tablet Strength During Tableting

Authors

    • Division of Pharmaceutical Technology, Faculty of PharmacyUniversity of Helsinki
  • Osmo Antikainen
    • Division of Pharmaceutical Technology, Faculty of PharmacyUniversity of Helsinki
  • Jyrki Heinämäki
    • Division of Pharmaceutical Technology, Faculty of PharmacyUniversity of Helsinki
    • Department of Pharmacy, Faculty of MedicineUniversity of Tartu
  • Jouko Yliruusi
    • Division of Pharmaceutical Technology, Faculty of PharmacyUniversity of Helsinki
Research Article

DOI: 10.1208/s12249-011-9623-0

Cite this article as:
Siiriä, S.M., Antikainen, O., Heinämäki, J. et al. AAPS PharmSciTech (2011) 12: 593. doi:10.1208/s12249-011-9623-0

Abstract

This study presents a new approach to model powder compression during tableting. The purpose of this study is to introduce a new discrete element simulation model for particle–particle bond formation during tablet compression. This model served as the basis for calculating tablet strength distribution during a compression cycle. Simulated results were compared with real tablets compressed from microcrystalline cellulose/theophylline pellets with various compression forces. Simulated and experimental compression forces increased similarly. Tablet-breaking forces increased with the calculated strengths obtained from the simulations. The calculated bond strength distribution inside the tablets showed features similar to those of the density and pressure distributions in the literature. However, the bond strength distributions at the center of the tablets varied considerably between individual tablets.

Key words

bondingbreaking strengthcompactionsimulationtableting

Supplementary material

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Copyright information

© American Association of Pharmaceutical Scientists 2011