Research Article

AAPS PharmSciTech

, Volume 11, Issue 3, pp 1257-1267

First online:

A Statistical Approach to Optimize the Spray Drying of Starch Particles: Application to Dry Powder Coating

  • Luca BilancettiAffiliated withENITIAA
  • , Denis PonceletAffiliated withENITIAA
  • , Catherine LoiselAffiliated withENITIAA
  • , Stefania MazzitelliAffiliated withDepartment of Chemistry and Technology of Drugs, University of Perugia
  • , Claudio NastruzziAffiliated withDepartment of Chemistry and Technology of Drugs, University of Perugia Email author 

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This article describes the preparation of starch particles, by spray drying, for possible application to a dry powder coating process. Dry powder coating consists of spraying a fine powder and a plasticizer on particles. The efficiency of the coating is linked to the powder morphological and dimensional characteristics. Different experimental parameters of the spray-drying process were analyzed, including type of solvent, starch concentration, rate of polymer feeding, pressure of the atomizing air, drying air flow, and temperature of drying air. An optimization and screening of the experimental parameters by a design of the experiment (DOE) approach have been done. Finally, the produced spray-dried starch particles were conveniently tested in a dry coating process, in comparison to the commercial initial starch. The obtained results, in terms of coating efficiency, demonstrated that the spray-dried particles led to a sharp increase of coating efficiency value.


dry coating microparticles spray drying starch