AAPS PharmSciTech

, Volume 11, Issue 3, pp 1257–1267

A Statistical Approach to Optimize the Spray Drying of Starch Particles: Application to Dry Powder Coating

  • Luca Bilancetti
  • Denis Poncelet
  • Catherine Loisel
  • Stefania Mazzitelli
  • Claudio Nastruzzi
Research Article

DOI: 10.1208/s12249-010-9492-y

Cite this article as:
Bilancetti, L., Poncelet, D., Loisel, C. et al. AAPS PharmSciTech (2010) 11: 1257. doi:10.1208/s12249-010-9492-y
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Abstract

This article describes the preparation of starch particles, by spray drying, for possible application to a dry powder coating process. Dry powder coating consists of spraying a fine powder and a plasticizer on particles. The efficiency of the coating is linked to the powder morphological and dimensional characteristics. Different experimental parameters of the spray-drying process were analyzed, including type of solvent, starch concentration, rate of polymer feeding, pressure of the atomizing air, drying air flow, and temperature of drying air. An optimization and screening of the experimental parameters by a design of the experiment (DOE) approach have been done. Finally, the produced spray-dried starch particles were conveniently tested in a dry coating process, in comparison to the commercial initial starch. The obtained results, in terms of coating efficiency, demonstrated that the spray-dried particles led to a sharp increase of coating efficiency value.

KEY WORDS

dry coatingmicroparticlesspray dryingstarch

Copyright information

© American Association of Pharmaceutical Scientists 2010

Authors and Affiliations

  • Luca Bilancetti
    • 1
  • Denis Poncelet
    • 1
  • Catherine Loisel
    • 1
  • Stefania Mazzitelli
    • 2
  • Claudio Nastruzzi
    • 2
  1. 1.ENITIAANantes Cedex 3France
  2. 2.Department of Chemistry and Technology of DrugsUniversity of PerugiaPerugiaItaly