Preparation and Evaluation of Microemulsion Systems Containing Salicylic Acid
First Online: 09 September 2009 Received: 23 August 2008 Accepted: 20 August 2009 DOI:
Cite this article as: Badawi, A.A., Nour, S.A., Sakran, W.S. et al. AAPS PharmSciTech (2009) 10: 1081. doi:10.1208/s12249-009-9301-7 Abstract
Microemulsions (MEs) are clear, thermodynamically stable systems. They were used to solubilize drugs and to improve topical drug availability. Salicylic acid (SA) is a keratolytic agent used in topical products with antimicrobial actions. The objective of this work was to prepare and evaluate SA ME systems. Different concentrations of SA were incorporated in an ME base composed of isopropyl myristate, water, and Tween 80: propylene glycol in the ratio of 15:1. Three ME systems were prepared: S
2%, S 5%, and S 10% which contain 2%, 5%, and 10% of SA, respectively. Evaluation by examination under cross-polarizing microscope, measuring of percent transmittance, pH measurement, determination of the specific gravity, assessment of rheological properties, and accelerated stability study were carried out. The data showed that the addition of SA markedly affected the physical properties of the base. All systems were not affected by accelerated stability tests. Stability study for 6 months under ambient conditions was carried out for S 10%. No remarkable changes were recorded except a decrease in the viscosity value after 1 month. The results suggested that ME could be a suitable vehicle for topical application of different concentrations of SA. Key words microemulsion salicylic acid stability REFERENCES
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