AAPS PharmSciTech

, Volume 10, Issue 2, pp 437–442

Development and Evaluation of Ethyl Cellulose-Based Transdermal Films of Furosemide for Improved In Vitro Skin Permeation

Authors

    • Formulation Development DepartmentAmneal Pharmaceutical Company (I) Pvt ltd
  • Chitral Mallikarjuna Setty
    • Department of PharmaceuticsN.E.T. Pharmacy College
  • Gaurav N. Mistry
    • Formulation Development DepartmentAmneal Pharmaceutical Company (I) Pvt ltd
  • Santnu L. Patel
    • Formulation Development DepartmentAmneal Pharmaceutical Company (I) Pvt ltd
  • Tarun J. Patel
    • Formulation Development DepartmentAmneal Pharmaceutical Company (I) Pvt ltd
  • Pritesh C. Mistry
    • Formulation Development DepartmentAmneal Pharmaceutical Company (I) Pvt ltd
  • Amar K. Rana
    • Formulation Development DepartmentAmneal Pharmaceutical Company (I) Pvt ltd
  • Pritesh K. Patel
    • Department of PharmaceuticsManoharbhai Patel Institute of Pharmacy
  • Rishabh S. Mishra
    • Department of PharmaceuticsManoharbhai Patel Institute of Pharmacy
Research Article

DOI: 10.1208/s12249-009-9224-3

Cite this article as:
Patel, D.P., Setty, C.M., Mistry, G.N. et al. AAPS PharmSciTech (2009) 10: 437. doi:10.1208/s12249-009-9224-3

Abstract

Transdermal films of the furosemide were developed employing ethyl cellulose and hydroxypropyl methylcellulose as film formers. The effect of binary mixture of polymers and penetration enhancers on physicochemical parameters including thickness, moisture content, moisture uptake, drug content, drug–polymer interaction, and in vitro permeation was evaluated. In vitro permeation study was conducted using human cadaver skin as penetration barrier in modified Keshary–Chein diffusion cell. In vitro skin permeation study showed that binary mixture, ethyl cellulose (EC)/hydroxypropyl methylcellulose (HPMC), at 8.5:1.5 ratio provided highest flux and also penetration enhancers further enhanced the permeation of drug, while propylene glycol showing higher enhancing effect compared to dimethyl sulfoxide and isopropyl myristate. Different kinetic models, used to interpret the release kinetics and mechanism, indicated that release from all formulations followed apparent zero-order kinetics and non-Fickian diffusion transport except formulation without HPMC which followed Fickian diffusion transport. Stability studies conducted as per International Conference on Harmonization guidelines did not show any degradation of drug. Based on the above observations, it can be reasonably concluded that blend of EC–HPMC polymers and propylene glycol are better suited for the development of transdermal delivery system of furosemide.

Key words

chemical penetration enhancersethyl cellulosefurosemidehydroxypropyl methylcellulosein vitro skin permeationtransdermal films

Copyright information

© American Association of Pharmaceutical Scientists 2009