The AAPS Journal

, Volume 16, Issue 2, pp 299–310

Ethinyl Estradiol and Other Human Pharmaceutical Estrogens in the Aquatic Environment: A Review of Recent Risk Assessment Data

  • James P. Laurenson
  • Raanan A. Bloom
  • Stephen Page
  • Nakissa Sadrieh
Review Article Theme: Pharmaceuticals and Personal Care Products in the Environment

DOI: 10.1208/s12248-014-9561-3

Cite this article as:
Laurenson, J.P., Bloom, R.A., Page, S. et al. AAPS J (2014) 16: 299. doi:10.1208/s12248-014-9561-3
Part of the following topical collections:
  1. Theme: Pharmaceuticals and Personal Care Products in the Environment

Abstract

Interest in pharmaceuticals in the environment has increased substantially in recent years. Several studies in particular have assessed human and ecological risks from human pharmaceutical estrogens, such as 17α-ethinyl estradiol (EE2). Regulatory action also has increased, with the USA and other countries developing rules to address estrogens and other pharmaceuticals in the environment. Accordingly, the Center for Drug Evaluation and Research at the US Food and Drug Administration has conducted a review and analysis of current data on the long-term ecological exposure and effects of EE2 and other estrogens. The results indicate that mean-flow long-term predicted environmental concentrations (PECs) of EE2 in approximately 99% or more of US surface water segments downstream of wastewater treatment plants are lower than a predicted no-effect concentration (PNEC) for aquatic chronic toxicity of 0.1 ng/L. Exceedances are expected to be primarily in localized, effluent-dominated water segments. The median mean-flow PEC is more than two orders of magnitude lower than this PNEC. Similar results exist for other pharmaceutical estrogens. Data also suggest that the contribution of EE2 more broadly to total estrogenic load in the environment from all sources (including other human pharmaceutical estrogens, endogenous estrogens, natural environmental estrogens, and industrial chemicals), while highly uncertain and variable, appears to be relatively low overall. Additional data and a more comprehensive approach for data collection and analysis for estrogenic substances in the environment, especially in effluent-dominated water segments in sensitive environments, would more fully characterize the risks.

KEY WORDS

aquatic ecologyenvironmental impactestrogensregulatory sciencetoxicity

Copyright information

© American Association of Pharmaceutical Scientists 2014

Authors and Affiliations

  • James P. Laurenson
    • 1
  • Raanan A. Bloom
    • 1
  • Stephen Page
    • 2
  • Nakissa Sadrieh
    • 3
  1. 1.Office of Pharmaceutical Science, Center for Drug Evaluation and ResearchUS Food and Drug AdministrationSilver SpringUSA
  2. 2.American Institutes for ResearchWashingtonUSA
  3. 3.Office of Cosmetics and Colors, Center for Food Safety and Applied NutritionUS Food and Drug AdministrationCollege ParkUSA