, Volume 15, Issue 4, pp 897-900
Date: 16 Jul 2013

Immunogenicity of Subcutaneously Administered Therapeutic Proteins—a Mechanistic Perspective

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The administration of therapeutic proteins via the subcutaneous route (sc) is desired for compliance and convenience, but could be challenging due to perceived immunogenic potential or unwanted immune responses. There are clinical and preclinical data supporting as well as refuting the generalized notion that sc is more immunogenic. We provide a mechanistic perspective of immunogenicity of therapeutic proteins administered via the sc route and discuss strategies and opportunities for novel therapeutic approaches to mitigate immunogenicity.