The AAPS Journal

, Volume 13, Issue 4, pp 662–664

Holford NHG and Sheiner LB “Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models”, Clin Pharmacokin 6:429–453 (1981)—The Backstory

Commentary Theme: Landmark Publications in the Pharmaceutical Sciences: The Backstory

DOI: 10.1208/s12248-011-9306-5

Cite this article as:
Holford, N. AAPS J (2011) 13: 662. doi:10.1208/s12248-011-9306-5



Copyright information

© American Association of Pharmaceutical Scientists 2011

Authors and Affiliations

  1. 1.Clinical PharmacologyUniversity of AucklandAucklandNew Zealand