The AAPS Journal

, 11:109

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

Authors

    • Department of Biochemistry & Molecular PharmacologyUniversity of Massachusetts Medical School
    • Department of MedicineUniversity of Massachusetts Medical School
  • Robert B. Zurier
    • Department of MedicineUniversity of Massachusetts Medical School
NIDA Symposium: Drugs of Abuse: Drug Development and Cannabinoids

DOI: 10.1208/s12248-009-9084-5

Cite this article as:
Burstein, S.H. & Zurier, R.B. AAPS J (2009) 11: 109. doi:10.1208/s12248-009-9084-5

Abstract

This review covers reports published in the last 5 years on the anti-inflammatory activities of all classes of cannabinoids, including phytocannabinoids such as tetrahydrocannabinol and cannabidiol, synthetic analogs such as ajulemic acid and nabilone, the endogenous cannabinoids anandamide and related compounds, namely, the elmiric acids, and finally, noncannabinoid components of Cannabis that show anti-inflammatory action. It is intended to be an update on the topic of the involvement of cannabinoids in the process of inflammation. A possible mechanism for these actions is suggested involving increased production of eicosanoids that promote the resolution of inflammation. This differentiates these cannabinoids from cyclooxygenase-2 inhibitors that suppress the synthesis of eicosanoids that promote the induction of the inflammatory process.

Key words

ajulemic acidcannabinoidelmiric acidendocannabinoidinflammation

Abbreviations

AJA

ajulemic acid

AG

arachidonoyl glycerol

CBCr

cannabichromene

CBD

cannabidiol

CBN

cannabinol

EC

endocannabinoid

EMA

elmiric acid

FAAH

fatty acid amidohydrolase

PEA

palmitoyl ethanolamide

THC

tetrahydrocannabinol

Copyright information

© American Association of Pharmaceutical Scientists 2009