AAPS PharmSciTech

, Volume 6, Issue 4, pp E649–E654

Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note


    • Department of Pharmaceutical SciencesNagpur University Campus
  • Suniket V. Fulzele
    • Department of Pharmaceutical SciencesNagpur University Campus
  • Avinash K. Dorle
    • Department of Pharmaceutical SciencesNagpur University Campus

DOI: 10.1208/pt060481

Cite this article as:
Satturwar, P.M., Fulzele, S.V. & Dorle, A.K. AAPS PharmSciTech (2005) 6: E649. doi:10.1208/pt060481


Results from the present study conclude that PR in combination with PVP and with incorporation of dibutyl phthalate (30% wt/wt) produces smooth flexible films with improved tensile strength and percentage elongation. The release rate of drug from films and permeation across skin increases with increase in drug and PVP loading but is independent of film thickness. Patches containing PR:PVP (7:3) show promise for pharmacokinetic and pharmacodynamic performance evaluation in a suitable animal model. In view of the overall results reported in the present study, it may be proposed that PR can be used in the design of a matrix type transdermal drug delivery system to prolong the drug release.


polymerized rosindiltiazem hydrochloridematrix systemin vitro releasein vitro permeationtransdermal drug delivery

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© American Association of Pharmaceutical Scientists 2005