Article

AAPS PharmSci

, Volume 3, Issue 3, pp 81-85

First online:

Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent pharmaceutical topical gel formulation

  • Mark S. KemperAffiliated withThermo Nicolet Corporation Email author 
  • , Edgar J. MagnusonAffiliated withThermo Nicolet Corporation
  • , Stephen R. LowryAffiliated withThermo Nicolet Corporation
  • , William J. McCarthyAffiliated withThermo Nicolet Corporation
  • , Napasinee AksornkoaeAffiliated withDepartment of Pharmaceutical Sciences, The University of Tennessee, College of Pharmacy
  • , D. Christopher WattsAffiliated withDepartment of Pharmaceutical Sciences, The University of Tennessee, College of Pharmacy
  • , James R. JohnsonAffiliated withDepartment of Pharmaceutical Sciences, The University of Tennessee, College of Pharmacy
  • , Atul J. ShuklaAffiliated withDepartment of Pharmaceutical Sciences, The University of Tennessee, College of Pharmacy

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Abstract

The objective of this study was to demonstrate the use of transmission Fourier transform near-infrared (FT-NIR) spectroscopy for quantitative analysis of an active ingredient in a translucent gel formulation. Gels were prepared using Carbopol 980 with 0%, 1%, 2%, 4%, 6%, and 8% ketoprofen and analyzed with an FT-NIR spectrophotometer operated in the transmission mode. The correlation coefficient of the calibration was 0.9996, and the root mean squared error of calibration was 0.0775%. The percent relative standard deviation for multiple measurements was 0.10%. The results prove that FT-NIR can be a good alternative to other, more time-consuming means of analysis for these types of formulations.

Keywords

FT-NIR Transmission Spectroscopy Carbopol Topical Formulations Ketoprofen