AAPS PharmSci

, Volume 3, Issue 3, pp 81–85

Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent pharmaceutical topical gel formulation

  • Mark S. Kemper
  • Edgar J. Magnuson
  • Stephen R. Lowry
  • William J. McCarthy
  • Napasinee Aksornkoae
  • D. Christopher Watts
  • James R. Johnson
  • Atul J. Shukla
Article

DOI: 10.1208/ps030323

Cite this article as:
Kemper, M.S., Magnuson, E.J., Lowry, S.R. et al. AAPS PharmSci (2001) 3: 81. doi:10.1208/ps030323

Abstract

The objective of this study was to demonstrate the use of transmission Fourier transform near-infrared (FT-NIR) spectroscopy for quantitative analysis of an active ingredient in a translucent gel formulation. Gels were prepared using Carbopol 980 with 0%, 1%, 2%, 4%, 6%, and 8% ketoprofen and analyzed with an FT-NIR spectrophotometer operated in the transmission mode. The correlation coefficient of the calibration was 0.9996, and the root mean squared error of calibration was 0.0775%. The percent relative standard deviation for multiple measurements was 0.10%. The results prove that FT-NIR can be a good alternative to other, more time-consuming means of analysis for these types of formulations.

Keywords

FT-NIRTransmission SpectroscopyCarbopolTopical FormulationsKetoprofen

Copyright information

© American Association of Pharmaceutical Scientists 2001

Authors and Affiliations

  • Mark S. Kemper
    • 1
  • Edgar J. Magnuson
    • 1
  • Stephen R. Lowry
    • 1
  • William J. McCarthy
    • 1
  • Napasinee Aksornkoae
    • 2
  • D. Christopher Watts
    • 2
  • James R. Johnson
    • 2
  • Atul J. Shukla
    • 2
  1. 1.Thermo Nicolet CorporationMadison
  2. 2.Department of Pharmaceutical Sciences, The University of TennesseeCollege of PharmacyMemphis