Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent pharmaceutical topical gel formulation Authors
First Online: 01 September 2001 Received: 18 April 2001 Accepted: 02 August 2001 DOI:
Cite this article as: Kemper, M.S., Magnuson, E.J., Lowry, S.R. et al. AAPS PharmSci (2001) 3: 81. doi:10.1208/ps030323 Abstract
The objective of this study was to demonstrate the use of transmission Fourier transform near-infrared (FT-NIR) spectroscopy for quantitative analysis of an active ingredient in a translucent gel formulation. Gels were prepared using Carbopol 980 with 0%, 1%, 2%, 4%, 6%, and 8% ketoprofen and analyzed with an FT-NIR spectrophotometer operated in the transmission mode. The correlation coefficient of the calibration was 0.9996, and the root mean squared error of calibration was 0.0775%. The percent relative standard deviation for multiple measurements was 0.10%. The results prove that FT-NIR can be a good alternative to other, more time-consuming means of analysis for these types of formulations.
Keywords FT-NIR Transmission Spectroscopy Carbopol Topical Formulations Ketoprofen
Published: August 26 2001
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