AAPS PharmSci

, Volume 3, Issue 2, pp 14–24

Preparation and characterization of gelatin surface modified PLGA microspheres

Article

DOI: 10.1208/ps030211

Cite this article as:
Jamie Tsung, M. & Burgess, D.J. AAPS PharmSci (2001) 3: 14. doi:10.1208/ps030211

Abstract

This study optimized conditions for preparing and characterizing gelatin surface modified poly (lactic-co-glycolic acid) (PLGA) copolymer microspheres and determined this systems interaction with fibronectin. Some gelatin microspheres have an affinity for fibronectin-bearing surfaces; these miscrospheres exploit the interaction between gelatin and fibronectin. PLGA copolymer microspheres were selected because they have reproducible and slowrelease characteristics in vivo. The PLGA microspheres were surface modified with gelatin to impart fibronectin recognition. Dexamethasone was incorporated into these microspheres because dexamethasone is beneficial in chronic human diseases associated with extra fibronectin expression (eg, cardiovascular disease, inflammatory disorders, rheumatoid arthritis). The gelatin surface modified PLGA microspheres (prepared by adsorption, conjugation, and spray coating) were investigated and characterized by encapsulation efficiency, particle size, in vitro release, and affinity for fibronectin. The gelatincoated PLGA microspheres had higher interaction with fibronectin compared with the other gelatin surface modified PLGA microspheres (adsorption and conjugation). Dexamethasone was released slowly (over 21 days) from gelatin surface modified PLGA microspheres.

Key Words

Microspheres Surface Modification Gelatin Fibronectin PLGA Dexamethasone 

Copyright information

© American Association of Pharmaceutical Scientists 2001

Authors and Affiliations

  1. 1.Lavipharm Laboratory IncEast Windsor
  2. 2.Department of Pharmaceutical Sciences, School of PharmacyUniversity of ConnecticutStorrs

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