Complex roles of filamin-A mediated cytoskeleton network in cancer progression
Filamin-A (FLNA), also called actin-binding protein 280 (ABP-280), was originally identified as a non-muscle actin binding protein, which organizes filamentous actin into orthogonal networks and stress fibers. Filamin-A also anchors various transmembrane proteins to the actin cytoskeleton and provides a scaffold for a wide range of cytoplasmic and nuclear signaling proteins. Intriguingly, several studies have revealed that filamin-A associates with multiple non-cytoskeletal proteins of diverse function and is involved in several unrelated pathways. Mutations and aberrant expression of filamin-A have been reported in human genetic diseases and several types of cancer. In this review, we discuss the implications of filamin-A in cancer progression, including metastasis and DNA damage response.
- Complex roles of filamin-A mediated cytoskeleton network in cancer progression
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Cell & Bioscience
- Online Date
- February 2013
- Online ISSN
- BioMed Central
- Additional Links
- Actin filament
- DNA repair
- Author Affiliations
- 1. Department of Radiation Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA
- 2. Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA