Cost-effectiveness of three malaria treatment strategies in rural Tigray, Ethiopia where both Plasmodium falciparum and Plasmodium vivax co-dominate
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Malaria transmission in Ethiopia is unstable and the disease is a major public health problem. Both, p.falciparum (60%) and p.vivax (40%) co-dominantly exist. The national guideline recommends three different diagnosis and treatment strategies at health post level: i) the use of a p.falciparum/vivax specific RDT as diagnosis tool and to treat with artemether-lumefantrine (AL), chloroquine (CQ) or referral if the patient was diagnosed with p.falciparum, p.vivax or no malaria, respectively (parascreen pan/pf based strategy); ii) the use of a p.falciparum specific RDT and AL for p.falciparum cases and CQ for the rest (paracheck pf based strategy); and iii) the use of AL for all cases diagnosed presumptively as malaria (presumptive based strategy). This study aimed to assess the cost-effectiveness of the recommended three diagnosis and treatment strategies in the Tigray region of Ethiopia.
The study was conducted under a routine health service delivery following the national malaria diagnosis and treatment guideline. Every suspected malaria case, who presented to a health extension worker either at a village or health post, was included. Costing, from the provider's perspective, only included diagnosis and antimalarial drugs. Effectiveness was measured by the number of correctly treated cases (CTC) and average and incremental cost-effectiveness calculated. One-way and two-way sensitivity analyses were conducted for selected parameters.
In total 2,422 subjects and 35 health posts were enrolled in the study. The average cost-effectiveness ratio showed that the parascreen pan/pf based strategy was more cost-effective (US$1.69/CTC) than both the paracheck pf (US$4.66/CTC) and the presumptive (US$11.08/CTC) based strategies. The incremental cost for the parascreen pan/pf based strategy was US$0.59/CTC to manage 65% more cases. The sensitivity analysis also confirmed parascreen pan/pf based strategy as the most cost-effective.
This study showed that the parascreen pan/pf based strategy should be the preferred option to be used at health post level in rural Tigray. This finding is relevant nationwide as the entire country's malaria epidemiology is similar to the study area.
Malaria continues to be a global challenge with half of the world's population at risk of the disease. In 2006 about 250 million episodes of malaria occurred globally with nearly a million deaths, mostly of children under 5 years of age. More than 85% of this disease burden was concentrated in countries in Sub-Saharan Africa (SSA). Ethiopia was one of the five main contributors to the overall African malaria burden [1, 2].
In Ethiopia, despite the long history of malaria control since the 1950s, the disease is still a major public health problem. Though some improvements, both in mortality and morbidity, have been recently achieved, malaria has been consistently reported as one of the three leading causes of morbidity and mortality over the past years . Malaria in Ethiopia is seasonal, predominantly unstable and focal, depending largely on rainfall and altitude. Two transmission seasons are known: major (September to December) and minor (April to May). The unstable nature of malaria makes the population non-immune and prone to focal and cyclical epidemics. Unlike most SSA countries where p.falciparum almost accounts for all malaria infection, in Ethiopia, both p.falciparum and p.vivax are co-dominant, the former accounting for approximately 60% of all cases. In the low transmission season p.vivax increases its proportion due to its relapsing nature and the seasonal drop in p.falciparum infection [3, 5, 6].
In fighting against this deadly disease, early diagnosis and prompt treatment is one of the most basic and effective global strategies [7, 8]. The effectiveness of this strategy is highly dependent on the national policy of providing effective diagnosis and first-line antimalarial drugs, and in the delivery system.
In 2004, Ethiopia made two important policy changes which favoured this strategy. Firstly, it launched a community-based health care system, the Health Extension Programme (HEP), to achieve significant essential health care coverage. HEP is the grass-root level of the primary health care (PHC) through the provision of two health extension workers (HEWs) in a health post (HP) at tabia (sub-district) level to serve approximately 5,000 inhabitants. HEWs are high school graduated women with one year of training on the components of the HEP programmes. HEP is a package of sixteen basic health components. All components of the programme comprise health promotion and prevention activities except the malaria intervention which, in addition, incorporates diagnosis and treatment . HEP has been successfully implemented throughout the country including Tigray. Currently, there are more than 1,220 health extension workers in Tigray and the coverage has increased from 30% in 2006/7 to above 70% in 2007/8 .
Secondly, the country has made two changes on its national malaria diagnosis and treatment guideline. Malaria confirmatory diagnosis using rapid diagnostic tests (RDTs) replaced presumptive diagnosis, while maintaining the latter approach where the former is unavailable . A presumptive malaria case is a patient who exhibits fever or history of fever within the past 48 hrs in the absence of clear symptoms indicating alternative causes of fever. RDTs are tests based on the detection of antigens released from the malaria parasites in lysed blood . The second change included a shift in the treatment of p.falciparum from monotherapy sulphadoxine-pyrimethamine (SP) to artemisinin-based combination therapy (ACT), namely artemether-lumefantrine (AL), while keeping chloroquine (CQ) for treating p.vivax. The guideline recommends three different diagnosis and treatment strategies: i) if malaria is diagnosed with a falciparum-specific and pan-specific device, treat p.falciparum cases with AL, p.vivax with CQ and refer negatives to a higher level; ii) if malaria is diagnosed with only a p.falciparum-specific device, treat positive (p.falciparum) cases with AL and all the remaining with CQ; and iii) if malaria is diagnosed presumptively, treat all suspected cases with AL . P.falciparum positive patients for whom AL is contra-indicated have to be treated with quinine and patients with one or more signs and symptoms of severity should be referred immediately to the nearest higher facility.
In the study year, 2007, on top of the presumptive diagnosis, two types of RDTs were in use at the health-post level in the study area: parascreen pan/pf (Zephyr Biomedical, Goa, India) and paracheck pf (Orchid Biomedical Systems, Goa, India); the former is able to identify both p.falciparum and p.vivax while the latter targets only p.falciparum. While paracheck pf was the commonly used RDT at health post level since 2004, parascreen pan/pf had been recently introduced.
Several studies on RDT cost-effectiveness (CE) have been conducted in the past years. Most of these studies were focused in areas of high malaria transmission and p.falciparum. Almost all were comparing potentially similar types of RDTs either with microscope and/or presumptive diagnosis [12–18]. However, none of them are similar to the Ethiopia malaria epidemiological context and to the current national diagnosis and treatment strategies.
Therefore, this operational research was designed to assess the cost-effectiveness of the recommended three diagnosis and treatment strategies in the Tigray region of Ethiopia. This will provide evidence to assist decision makers on which strategy is the most appropriate in the region
Tigray regional state is located in northern Ethiopia and is divided into 47 woredas (districts). The region has approximately 4.3 million inhabitants most of whom (81.2%) live in rural areas . The majority of the population works in agriculture. Famine and drought are regular occurrences in the region. As in the rest of Ethiopia, malaria transmission in Tigray is very seasonal and occurs mainly at altitudes up to 2,200 meters above sea level (masl). Around 65% of the population is at risk of malaria and the disease was the number one cause of outpatient cases, admissions and deaths. In 2006, it accounted for 28% of all the patients treated in the regions' health facilities . Previous efforts to control the problem have included insecticide residual spraying and environmental management. Since 2005, distribution of long-lasting insecticidal nets is gradually covering all malarious villages.
The health system in Tigray is essentially the same as in the rest of Ethiopia, i.e., a four-tier system with Primary Health Care Units (PHCUs) at the grass-roots level. There are five zone-level hospitals, six district hospitals and one referral hospital in Mekelle, the capital.
In order to capture epidemiological variations, the study was stratified into the three commonly known malaria strata in the country: stratum-I (<1000 masl), stratum-II (1000-1500 masl) and stratum-III (1501-2000 masl). A district in a given stratum with a high number of villages was selected to represent its respective stratum. Four districts were selected: Kafta-Humera, Tahtay-Adiyabo, and Mereb-leke plus Raya-Azebo from strata I, II, and III respectively. Two districts were included in the strata III for being the largest strata. The districts populations ranged from 91,379 in Tahtay-Adiyabo to 136,039 in Raya-Azebo. In all the study districts, malaria has constituted a leading cause of the disease burden over years. For instance, in 2007/8 it accounted for 21%-28% of outpatient visits in the districts .
The study was conducted under a routine HEP service following the national malaria diagnosis and treatment guideline during the main transmission months of 2007. Half of the health posts (7-8) in each district were randomly selected.
Patient enrolment and management
All diagnosis and treatment procedures were done by the HEWs under routine conditions following the national guideline. HEWs (enumerators) were trained with a major focus on how to interpret the result of the newly introduced parascreen pan/pf device, blood film preparation and data collection. No additional training was given on paracheck pf as it had been used for years.
Every suspected malaria case, who presented to a HEW either at a village or health post, was included. Following the national malaria guideline, patients were excluded if they: i) exhibited signs and symptoms of severe malaria or any other severe disease, ii) had taken antimalarial drugs (AL or quinine) within the previous two weeks, and iii) were infants under three-months-old or were pregnant mothers during their first trimester for whom AL is contraindicated.
Previous years have shown a slide positivity rate (SPR) of approximately 30% in the high-transmission season . For this anticipated SPR, with a confidence level of 95%, an absolute precision of five percentage points (25% to 35%) and a design effect of two), the required sample size was 646 patients for each stratum.
Patient history, including demographic data, signs and symptoms related to current illness (chief complaint) and medication, was collected. A finger-pricked blood sample from each subject was taken for the two types of RDTs, according to the RDT manufacturer's instructions (leaflet enclosed within the kit) and a blood film (thick and thin) for the microscope examination following the World Health Organization (WHO) guideline . Patients were treated for malaria if one of the RDTs was positive.
The reference expert microscopy
Performance of the three alternative diagnostic and treatment strategies were calculated vis-à-vis the light microscopy. Blood films were stained with 3% Giemsa stain and examined by two independent (first and second) microscopists using ×1000 oil immersion following the WHO guideline . The independent readings were compared for concordance of presence or absence of asexual/sexual forms of plasmodium and its species. A third senior microscopist examined discordant slides and his/her findings taken as true diagnostic outcome. A negative was declared after 200 microscopic fields read without finding a parasite. The first and the second microscopists were unaware of the RDT results and the third reader was blind to the results of both the RDTs and the preceding microscopists.
The cost-effectiveness (CE) of the three different diagnosis and treatment strategies was compared. The strategies included: i) the use of parascreen pan/pf as diagnosis tool and to treat with AL, CQ or referral if the patient was diagnosed with p.falciparum, p.vivax or no malaria respectively (parascreen pan/pf based strategy); ii) the use of paracheck pf and AL for p.falciparum cases and CQ for the rest (paracheck pf based strategy); and iii) the use of AL for all cases diagnosed presumptively as malaria (presumptive based strategy). All data were entered in to Microsoft Excel version 8. Effectiveness was calculated using Epi Info™ version 3.5  and the cost and cost-effectiveness were calculated using Microsoft Excel 8.
Costing was undertaken from the provider's perspective (government) at the health post level and restricted only to the first visit of a patient. At this facility level, the entire malaria diagnosis and treatment service is free of charge.
Costing considered only diagnosis and antimalarial drugs because the fixed costs (infrastructure, supervision, training and HEWs salaries) were assumed not to differ among the comparative strategies. The cost of these items is also shared with other health programmes. RDT provision, compared to presumptive diagnosis, comprises other operational and management costs at different levels in addition to the cost of the test kit; however, this cost was reasonably assumed as similar for both RDT-based strategies and traded-off with the expenditure reduction on drug management and transport as RDT application decreased the amount of AL needed. RDT costing was at the manufacturer's price and was calculated as the total number of presumptive patients multiplied by the unit price of each type of RDT kit (including lancets, swabs, pipette, buffer solution and desiccant).
AL costing was calculated at the manufacturer's cost (but not CQ) as it has been provided at no profit, as per the special pricing agreement between WHO and the manufacturer . Antimalarial drug cost was calculated following the malaria diagnosis and treatment guideline at the peripheral level. Being age dependent, the number of cases in each treatment regimen was multiplied by the cost of the respective treatment course of either AL or CQ. Unit costs were obtained from the Tigray Health Bureau (THB) pharmacy unit for the year 2007. The following items were not including in costing: RDT reading time, RDT wastage and RDT training cost.
Effectiveness indicator and cost-effectiveness measure
RDTs, highly specific and less sensitive compared to presumptive diagnosis, are mainly introduced since presumptive treatment is non-specific while it is 100% sensitive. Therefore, there is a need to balance the risk between improving specificity (excluding non-malaria cases) and reducing sensitivity (missing malaria cases) while replacing presumptive with RDTs. Taking this into account, we selected the number of correctly treated cases (CTC) as the measure of effectiveness on the basis of the malaria diagnosis and treatment strategies. This indicator accommodates both concerns: detecting the malaria cases (sensitivity) and excluding the non-malaria cases (specificity) supporting the public health goal of properly managing all causes of illness. In low malaria prevalence areas such as Tigray , all malaria infections, even with low-level parasitaemia, are associated with clinical illness in all age groups. In such malaria epidemiology, there is no evidence if missing malaria cases is more or less dangerous than missing non-malaria cases or the vice-versa. Therefore, it was assumed that the weight of correctly or mistakenly treating cases of any disease including malaria was equal. A non-malaria case identified by the parascreen pan/pf was referred to a higher health facility level - this meant that this patient was correctly treated. The number of correctly treated cases was then calculated as the number of true positives plus the number of true negatives cases.
Cost-effectiveness was estimated as average cost-effectiveness ratio (ACER) and incremental cost-effectiveness ratio (ICER). ACER was calculated as a cost of diagnosis and treatment of a given strategy divided by the number of CTCs. To find out if an extra cost in a strategy produced an extra effect (health benefit), ICER analysis was conducted where the strategies were ranked by increasing cost and then the additional cost in one strategy was divided by the additional CTCs .
Sensitivity analysis for selected parameters for which the cost-effectiveness is more sensitive was conducted. Changes in some variables may have skewed some findings; to allow for this, a one-way sensitivity analysis was carried out on changes in AL cost and SPR. A reduction in cost for AL was incorporated into the analysis since the price of AL has been constantly decreasing throughout the last few years (even though drug resistance may necessitate the purchase of more expensive antimalarial drugs in the future). We did not consider changes on RDT price, as it seems unlikely to drop in the near future for at least two possible reasons: firstly, there is a huge gap between the demand and supply - for instance, in 2006, only 16 million RDTs were distributed while 80 million courses of ACTs were used . Secondly, despite the potential high demand, the prices have been kept constant in the last years.
Change in SPR as a function of seasonal variation is inevitable. We considered a minor transmission season (the point estimate was of the major season), whilst assuming the diagnostic performance remained constant. A two-way sensitivity analysis was also carried out at a reduced AL cost during a low transmission season.
Ethical clearance was obtained from Tigray Health Bureau, Mekelle, Ethiopia. District Health Offices were informed of the study and its purposes. The purpose of the study was explained to the participants. Verbal consent was obtained from (patient/patient's guardian) as the majority of the rural population is illiterate. No patient refused to participate. Confidentiality of patient identity was maintained for every enrolled patient by assigning a unique identification number that was labelled on the RDT devices, blood film slides, data collection forms and database.
Characteristics of the subjects
In total 2,422 subjects from all three strata and 35 health posts were enrolled in the study. Overall, 26.63% (n = 645), 28.0% (n = 677) and 45.42% (n = 1100) of the subjects were from strata I, II and III, respectively. In total, 37.2% (n = 901) were female, 13.96% (n = 338) were children aged under five years, 18.66% (n = 452) aged between 5-14 years and the remaining 67.38% were 15 years or above. The age of the study subjects ranged from three months to 85 years with a mean of 24.18 (median of 21 years). Eighteen percent of them sought treatment within one day since the onset of illness. Most of the patients (86.21%) appeared with fever and the remaining with a history of fever.
The microscope examination of thick blood smear showed a crude (all species and all stages) SPR of 27.29% (n = 661) with 68.53% (n = 453) of the positive samples being p.falciparum (+/-gametocytes, gametocyte alone and mixed) and 31.47% (n = 208) p.vivax (+/- gametocytes) (Table 1). The stratified SPR was 46.51%, 26.88% and 16.27% with a p. falciparum proportion of 68%, 69.78% and 69.77% for stratum I, II and III, respectively. There were 27 cases of gametocytes, out of which 26 were in the presence of asexual stage. There was only one mixed infection of p.falciparum and p.vivax. From the operational point of view, all these 28 cases were considered as p.falciparum. There was one case of p.vivax in the presence of gametocytes which was considered as p.vivax. Summary result of the comparison between the expert microscopy and the RDTs, Tigray, Ethiopia, 2007. Expert Microscope Paracheck pf Parascreen pan/pf Total (microscope)
P.falciparum Positive 402 51 377 76 453 Negative 114 1855 97 1872 1969 Total 516 1906 474 1948 2422 P.vivax Positive - - 155 53 208 Negative - - 53 2161 2214 Total - - 208 2214 2422
Summary result of the comparison between the expert microscopy and the RDTs, Tigray, Ethiopia, 2007.
The unit cost was US$ 0.59 (US$ = 9.00 Ethiopian birr for 2007) for the paracheck pf kit, US$1.05 for the parascreen pan/pf kit and US$ 0.03 for a pair of gloves. A treatment course of AL cost US$ 0.60, 1.20, 1.80 and 2.40 according to the treatment regimen (age) group. Each CQ tablet cost US$0.006.
The cost analysis indicated that the presumptive-based strategy (BS) was higher by 27.69% and 46.1% than the cost of the parascreen-BS and paracheck-BS, respectively. In the RDT-BS, the tests' cost accounted for the majority of the expenditure, 55.52% in paracheck-BS and 72.08% in parascreen-BS. AL constituted 41%, 27.65% and 100% of the total cost of paracheck-BS, parascreen-BS and presumptive-BS, respectively. Cost of chloroquine was insignificant which was 3.48% in paracheck-BS and less than 1% in parascreen-BS.
Effectiveness indicator and cost-effectiveness
Out of the 661 malaria and 1761 non-malaria cases, parascreen-BS correctly treated 88.48% cases (377 p.falciparum, 155 p.vivax and 1611 negatives) (Table 2). It failed to identify 11.52% patients, out of which 5.33% were malaria patients (76 p.falciparum and 53 p.vivax) who would have been left untreated (false negatives) and 6.19% (97 false p.falciparum and 53 false p.vivax) would have been incorrectly given antimalarial drugs (Table 1). Paracheck-BS correctly treated 23.95% cases (402 p.falciparum and 178 p.vivax) and mislabelled 76.05% (n = 1842). Out of these, 3.34% were malaria (51 p.falciparum classified as p.vivax and 30 p.vivax as p.falciparum) and 72.70% (n = 1761) were non-malaria (114 cases classified as p.falciparum out of which 11 were p.vivax and 1647 as p.vivax when they were not). The presumptive-BS captured all the p.falciparum, (18.7%, n = 453) but mistreated 1969 cases (81.30%) as p.falciparum, out of which 8.59% (208) were p.vivax and 72.71% were non-malaria (Table 2). Effectiveness and cost ($US) of the three different diagnostic strategies, Tigray, Ethiopia, 2007 Description Different treatment strategies
Correctly treated p.falciparum cases 453 402 377 Correctly treated p.vivax cases 0 178 155 Correctly treated non-malaria cases 0 0 1611 Total correctly treated cases 453 (18.70) 580 (23.95) 2143 (88.48) Test Cost 0 1501.64(55.52) 2615.76(72.08) AL cost 5017.2 1108.80(41.00) 1003.20(27.65) CQ cost 0 94.05(3.48) 9.80(0.27) Total cost 5017.20 2704.49 3628.76
Effectiveness and cost ($US) of the three different diagnostic strategies, Tigray, Ethiopia, 2007
Different treatment strategies
Correctly treated p.falciparum cases
Correctly treated p.vivax cases
Correctly treated non-malaria cases
Total correctly treated cases
The CE analysis showed that the parascreen-BS was the most cost-effective with ACER US$ 1.69/CTC followed by US$ 4.66/CTC for the paracheck-BS and US$11.08/CTC for the presumptive-BS (Table 3). ICER analysis was conducted to find out whether this additional cost was worth paying to get the added effect. Presumptive-BS was highly dominated (less effect for more money) by parascreen-BS. Therefore, the ICER calculation was limited to parascreen-BS over paracheck-BS. At the base case, the additional cost on parascreen-BS over paracheck-BS would be able to treat an additional 64.5% (n = 1563) of patients correctly with an incremental cost of US$0.59/patient. Average and incremental cost-effectiveness ratios among the three diagnosis strategies, Tigray, Ethiopia, 2007. Diagnostic based strategy Cost Correctly treated cases ACER Incremental cost Incremental effect ICER Remark Paracheck 2704.5 580 4.66 - - - Parascreen 3628.8 2143 1.69 924.27 1563 0.59 Presumptive 5017.2 453 11.08 1388.44 -1690 -0.82 dominated
Average and incremental cost-effectiveness ratios among the three diagnosis strategies, Tigray, Ethiopia, 2007.
Diagnostic based strategy
Correctly treated cases
Taking into account the AL cost in the International Drug Price Indicator (2008 version) that showed a reduction of 32.8% (lowest dose), 33.25% (for the middle doses) and to 36.9% (adult dose) , a sensitivity analysis revealed a high reduction in the cost of the presumptive-BS by 37.14%, in paracheck-BS by 14.93% and in parascreen-BS by 10.05% (Table 4). The base case ACER was improved by 36.20% (from US$11.08 $US7.05) in presumptive-BS, by 14.81% (from US$ 4.66 to $US 3.97) in paracheck-BS and by 10.05% (from US$ 1.69 to $US 1.52) in parascreen-BS. Despite the significant drop in ACER, presumptive-BS was still dominated by parascreen-BS. The ICER of parascreen-BS over paracheck-BS was increased from $US0.59 to $US0.62 for each additional 1563 correctly treated cases. Sensitivity analysis at reduced AL cost and low-transmission for three malaria diagnostic strategies, Tigray, 2007 At reduced AL price Low transmission season (15% SPR)
Base case cost 2704.49 3629.76 5017.20 2704.49 3629.76 5017.2 Total new cost 2300.80 3264.20 3192.70 1926.05 2908.56 5017.20 Cost change within strategy 403.69 364.56 1886.50 778.44 720.20 0 Cost change in (%) (14.93) (10.05) (37.14) (28.78) (19.85) 0 Correctly treated cases (n, %) 580 (23.95) 2143 (88.48) 453 (18.7) 315 (13.01) 2253 (93.02) 127 (5.24) ACER at reduced AL and SPR 3.97 1.52 7.05 6.11 1.29 39.51 ACER Change from base case, % (14.81) (10.06) (36.2) (+31.1) (23.67) (+258) Cost difference b/n strategy 0.00 963.40 -71.50 0.00 982.51 2108.64 Effect difference b/n strategy 0.00 1563.00 -1690 0.00 1938 -2124 ICER - 0.62 dominated - 0.51 dominated
Sensitivity analysis at reduced AL cost and low-transmission for three malaria diagnostic strategies, Tigray, 2007
At reduced AL price
Low transmission season (15% SPR)
Base case cost
Total new cost
Cost change within strategy
Cost change in (%)
Correctly treated cases (n, %)
ACER at reduced AL and SPR
ACER Change from base case, %
Cost difference b/n strategy
Effect difference b/n strategy
The sensitivity analysis at 15% SPR during the minor transmission season with 35% p.falciparum to 65% p.vivax, with no change in the diagnostic performance of the strategies to the base case, showed a reduction in the proportion of correctly treated cases in the presumptive and paracheck-BS. The proportion of CTC was, however, increased in the parascreen-BS strategy (Table 4). The base case ACER decreased in parascreen-BS (from $US 1.69 to $US 1.29/CTC) and increased in the paracheck (from $US 4.66 to $US 6.11/CTC) and presumptive-BS (from $US 11.08 to $US 39.51/CTC) per correctly treated case. This illustrated that the cost-effectiveness increased by 23.67% in the parascreen-BS, decreased in the paracheck-BS by 31.12% and deteriorated significantly in the presumptive-BS by 258%. Since presumptive-BS was dominated, the IECR was recalculated as parascreen-BS over paracheck-BS. The base case of $US 0.59 dropped to $US 0.51/additional correctly treated case (Table 4).
A two-way sensitivity analysis (Table 5) at reduced cost of AL during the minor transmission season showed an increase in the ACER from $US 4.66 to $US 5.75 and from $US 11.08 to $US 25.14 in the paracheck-BS and presumptive-BS, respectively, while it dropped from $US 1.69 to $US 1.25 in the parascreen-BS. The two-way sensitivity analysis showed that presumptive-BS continued to be dominated by parascreen-BS. A two-way sensitivity cost-effectiveness analysis at reduced cost of AL during low-transmission season, Tigray, 2007. Diagnostic strategies Cost Correctly treated cases ACER Incremental cost Incremental effect ICER Paracheck-BS 1812.61 315 5.75 0 0 0 Parascreen-BS 2806.27 2253 1.25 993.66 1938 0.51 Presumptive-BS 3193.00 127 25.14 386.73 -2126 -0.18 (dominated)
A two-way sensitivity cost-effectiveness analysis at reduced cost of AL during low-transmission season, Tigray, 2007.
Correctly treated cases
This is, to our knowledge, the first empirical study in Ethiopia evaluating the economic implications of the malaria diagnostic and treatment strategies currently implemented in the country. It is also a unique study in that it compared two RDTs targeting different plasmodium-specific antigens (p.falciparum and p.vivax vs. only p.falciparum) from an operational point of view.
This study has supported two central facts regarding the malaria transmission pattern in the region: firstly, our result of SPR (27.3%) and species composition of p.falciparum to p.vivax (68.5% to 31.5%) is highly consistent with the commonly quoted statistics in serial reports of the THB . Secondly, it has confirmed that malaria in the region varies from place to place due to differing altitude. The SPR was 46.51% for the lower stratum, 26.88% for the middle, and 16% for the highest stratum whilst showing a similar proportion of p.falciparum to p.vivax (range 68%-69.78%). As many other studies have indicated [17, 27, 28], this research has also revealed that the shift from presumptive-BS to RDT-BS is clearly of significant benefit in the era of ACT. In our context where malaria transmission is low, the likelihood of a fever episode being due to malaria, even during the peak transmission season, is on average 30%. Approximately one-third of this corresponds to p.vivax, increasing to two-thirds during the minor transmission season. The prevalence and proportion of the species bitterly challenges the presumptive-BS strategy as it leads to mistreat numerous p.vivax and false non-malaria cases. The need of using RDT-BS is therefore not debatable. Instead, the discussion should be tailored toward which type of RDT is the more cost-effective to ensure the maximum number of patients receive appropriate treatment. Accordingly, parascreen-BS was found to be the more cost-effective. The ICER showed that, if we invest in parascreen-BS instead of paracheck-BS, we can properly manage 65% (1563) additional cases for as little as $ 0.59/patient. If we spend on presumptive-BS instead of parascreen-BS, the cost rises to US$ 0.82/patient (highly dominated). In fact, the cost-effectiveness of RDT-BS over presumptive-BS was partially increased at the expense of some missed malaria cases, since the RDTs are less sensitive than the presumptive-BS. We are also aware that if the effectiveness measure would have been only malaria cases, the paracheck-BS would have been the more cost-effective. However, the health benefit with the parascreen-BS is higher as more non-malaria cases get appropriate treatment and the saving is greater by avoiding over prescription. Over-treatment of malaria results in considerable morbidity and mortality by delaying the correct treatment of non-malaria illness and by contributing to the development and spread of antimalarial resistance strains.
The sensitivity analysis showed that the cost-effectiveness of the strategies varied depending on the season and AL cost. With the AL price drop, all alternatives improved their cost-effectiveness; however, in the low-transmission season, both the paracheck-BS and the presumptive-BS suffered while the parascreen-BS still improved. This shows that parascreen-BS is even more cost effective with reduced AL cost and during low-transmission season, which is the longest period of the year (December-August). Though no sensitivity analysis was made with regard to the different malaria strata, the higher the elevation, the lower the SPR makes parascreen pan/pf still more cost effective. Studies conducted in semi-immune populations have shown a higher cost effectiveness of RDTs in children <5 years compared to other age groups [14, 29]. In our case, where all age groups share practically equal risk of malaria, this sensitivity analysis was not relevant.
Though the literature on the cost-effectiveness of RDTs has been growing in the last years [12–18, 28], no comparable study designs to ours were found. The focus of all the studies has been on one type of plasmodium-specific RDT, either p.falciparum specific [13, 14, 17] or in combination with p.vivax [12, 16]. Our study compared both types of plasmodium-specific RDTs at the same time.
There are some considerations to take into account which can potentially affect the findings of this research. Firstly, our study was limited to the health-provider perspective at the rural health post level. If a full societal perspective had been used to capture the distributional impact of the intervention, the epidemiological and economical advantages of the best RDT-BS might have been even higher. One limitation was that the study design did not allow us to capture whether HEWs complied with the guideline in their therapeutic decision-making. The HEW prescription report might not show the actual practice. Experience from the field and recent studies have shown that health workers are prescribing antimalarial drugs regardless of negative test results [17, 30–35].
Cost calculation did not include the RDT reading time, RDT wastage and RDT training cost. The former is difficult to measure because the reading time might include attending several patients. RDTs could be wasted for different reasons such as poor transport, storage conditions and due to inappropriate use. To estimate these wastage's costs would have been extremely difficult. The few hours training on RDT, which it is a long-term investment, made also difficult to allocate the cost to the patients. In our study, weights to malaria and non-malaria cases were assumed to be equal since our study population is non-immune. In some studies conducted in semi-immune populations, more weight has been given to non-malaria patients because malaria severity is less in adults [13, 28].
The study has shown that the most cost-effective strategy was the one which used parascreen pan/pf in the treatment of malaria. The finding is relevant not only for Tigray region but also for the whole country, since malaria epidemiology follows a similar pattern nationally. Since 2008, the only available strategies at the health post level in the country have been the paracheck pf-BS and presumptive-BS. Our finding, pointing the superiority of the parascreen pan/pf based strategy, call decision-makers to reconsider this policy.
These results will be, however, pertinent only if an adequate supply of RDT and first-line antimalarial drugs at the health-post level are ensured and if HEWs comply with test results. Furthermore, and importantly, proper management of RDTs and adequate training and continuous supervision of HEWs should also be maintained. Finally, a study that captures the final health outcome of malaria diagnosis and treatment strategies and assesses HEWs' compliance with test results should be top research priorities in the region
We would like to thank Tigray Health Bureau, the staff of the Dept. of Malaria and Other Vector Borne Diseases Prevention and Control, and staff members of the study districts. We are very grateful to the HEWs for their valuable assistance. We are also indebted to all patients who consented to participate in this study.
This work was partly supported by the Umeå Centre for Global Health Research, funded by FAS, the Swedish Council for Working Life and Social Research (Grant no. 2006-1512).