World Journal of Surgical Oncology
© Antoniewicz et al. 2010
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
10.1186/1477-7819-8-63

Renal carcinoma infiltrating inferior vena cava and combined valvular heart disease - one-stage uro-cardiological procedure: a case report

Artur A Antoniewicz , Slawomir Poletajew , Andrzej Biederman , Lukasz Zapala  and Andrzej Borowka 
(1)
Department of Urology, The Medical Centre of Postgraduate Education, Warsaw, Poland
(2)
First Department of Cardiac Surgery, Institute of Cardiology, Warsaw, Poland
 
 
Artur A Antoniewicz
 
Slawomir Poletajew (Corresponding author)
 
Andrzej Biederman
 
Lukasz Zapala
 
Andrzej Borowka
Received: 3 February 2010Accepted: 28 July 2010Published online: 28 July 2010
Abstract
Standard treatment of patients with coexisting cardiac and non-cardiac diseases includes two separate operations. We report a case of 55-year-old man with combined valvular heart disease and renal carcinoma infiltrating inferior caval vein, who underwent one-stage cardio-urologic procedure. In the first step, mitral and tricuspid valvuloplasty were performed by cardiac surgeons. Then, urologists performed radical nephrectomy and thrombectomy. The postoperative course was uneventful. In twelve months follow-up the patient shows no signs of reccurrence and he had no symptoms of cardiac disease. To the best of our knowledge such a case has never been reported before in the literature.
Abbreviations
AVR
aortic valve replacement
CABG
coronary artery bypass grafting
CT
computed tomography
DC shock
direct current shock
EF
ejection fraction
NYHA
New York Heart Association
PASP
pulmonary arterial systolic pressure

Background

Coexistence of cardiac and non-cardiac diseases requiring surgical treatment has been a matter of debate for many years. The major problem concerns patients suffering from cardiac and oncologic diseases. The strategy of two separate procedures should be taken into consideration when consulting such a case. However, if the cardiac operation is performed first, the oncologic treatment is delayed and the chances for success are poorer. Furthermore, the immunosuppressive effect of extracorporeal circulation may accelerate tumor growth and disseminate cancer cells [1]. If oncologic operation is performed first, the risk of operation is very high due to heart status. There is also an aspect of risk and cost of two hospital stays and additional anaesthesia.
In this group of patients, cardiac and non-cardiac operation performed under single anaesthesia seems to be interesting therapeutic option. However, the combined procedure requires thorough operation plan and two experienced, harmonious surgical teams. Some surgeons have started to perform such procedures. Satisfactory results are reported concerning one-stage cardiac operation and pulmonary tumor resection [2], carotid endarterectomy [3], abdominal aortic aneurysm repair [4], resection of goiter [5] and others.
Till now there has been just few publications on one-stage cardio-urologic operations [69] and there are no reports concerning patients with combined valvular heart disease and urologic tumor.

Case presentation

55-year-old man (height 1,78 m; weight 70 kg) with severe heart failure - NYHA class III/IV was admitted to cardiology department for evaluation for surgery of incompetent mitral and tricuspid valves. Transthoracic echocardiogram confirmed diagnosis of severe mitral and tricuspid incompetence, dilated left ventricle, poor contractility (EF - 40%), pulmonary hypertension (PASP 90 mmHg).
On physical examination right lower abdomen mass was found and CT scan revealed large (12 cm × 11 cm × 7 cm) right kidney tumor with extension to infradiaphragmatic juxtahepatic part of inferior vena cava (caval thrombus 9 cm × 5 cm) (See Figures 1, 2, 3). Several options of treatment were considered but during discussion with cardiac surgeons and urologists one stage operation was decided and carefully planed.
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Figure 1
CT scan showing large tumor of the right kidney.
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Figure 2
CT scan showing involvement of infradiaphragmatic juxtahepatic part of inferior vena cava.
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Figure 3
CT reconstruction of the abdomen showing the size of the renal mass and the thrombus.
In preoperative period patient received hypotensive drugs (furosemide 0,04 g, spironolactone 0,025 g), beta-blocker (metoprolol 0,05 g), antyarrhytmic drug (amiodarone 0,2 g), anticoagulant (enoxaparin 0,06 g), potassium and magnesium.
Cardiac part of operation was performed first. Chest was open through median sternotomy and cardiopulmonary bypass (CPB) was established by cannulation of both venae cavae and ascending aorta. After clumping the aorta heart was stopped by cold blood cardioplegia, and both valves were repaired - dilated mitral annulus with C-G Future Band (Medtronic Inc.USA) and tricuspid annulus with De Vega plasty. After aortic clump was removed heart rhytm was restored with DC shock. CPB was discontinued without problems, patient was decannulated, heparin reversed with protamine. Transoesophageal echocardiogram confirmed good result of valves repair. The extracorporeal circulation time was 72 minutes, the aorta was clumped for 49 minutes.
The second part of the operation was carried out just after the patient was hemodynamically stable. Urologists performed right radical nephrectomy through laparotomy. Accurate localization of the thrombus was assessed intraoperatively and a decision not to use cardiopulmonary bypass for thrombectomy was made. The kidney, the adrenal gland and the thrombus were removed intact (Figure 4).
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Figure 4
Polymorphic appearance of renal cell carcinoma of size 12 × 11 × 7 cm.
The operation took 4 hours 25 minutes. Blood loss was 600 ml. 5 units of fresh frozen plasma (5 × 220 ml), 2 units of red blood cells (2 × 500 ml) and 1 unit of platelets were administered. There were no complications. Macroscopic evaluation of the specimen showed 10 × 10 × 9 cm renal mass and 6 × 3 × 4 cm neoplasmatic thrombus. Microscopic examination revealed clear cell carcinoma of the kidney at the stage G1 pT3bN0M0, not infiltrating renal capsule (Figure 5). 10 lymphatic nodules were negative.
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Figure 5
Pathological findings of renal cell carcinoma.
In postoperative echocardiography there were no signs of mitral either tricuspid incompetence or pericardial effusion. Electrocardiogram demonstrated regular sinus rhythm. In peri- and postoperative period patient received antibiotic prophylaxis (ceftriaxone 2,0 g), hypotensive drugs (furosemide 0,04 g, enalapril 0,05 g), beta-blocker (metoprolol 0,05 g), antyarrhytmic (amiodarone 0,2 g), anticoagulant (enoxaparin 0,06 g), acetylsalicylic acid (0,075 g), omeprazole (0,02 g), potassium and magnesium. 6 days after surgery oral anticoagulant therapy was started with acenocoumarol (0,002 g).
9 days after the operation the patient was transferred from cardiosurgical department to urologic centre. 4 days later he was discharged in good condition. 12-month follow-up showed that the patient remains without any complaints. Computed tomography demonstrated no signs of reccurrence.

Conclusions

To the best of our knowledge, this is the first reported case of patient, who underwent one-stage mitral valvuloplasty, tricuspid valvuloplasty and radical nephrectomy with inferior caval vein thrombecotmy. Coexistence of combined valvular heart disease with severe heart failure and renal cell carcinoma infiltrating renal and inferior caval vein rendered this operation as very high risk procedure. However, the strategy of two separate operations was contraindicated irrespective of the order of interventions. Cardiac operation in patient with virtually total obstruction of inferior caval vein could not make an expected profit and additionally could be significantly unfavourable due to the delay of oncological treatment. On the other hand the risk of urologic operation in patient with so advanced circulatory insufficiency would be extremely high.
Till now there has been 4 reports on simultaneous cardiac procedure and nephrectomy enrolling in total 9 cases [69]. Among them there are no reports on such complicated operations neither on one-stage tricuspid valve nor kidney operations (Table 1).
Table 1
Data from the literature concerning one-stage cardiac operation and nephrectomy
Author
Study dates
Number of patients
Cardiac procedure
Urologic procedure
Operative mortality
Complications
Mean follow-up time
Follow-up results
Franke [6]
2000
1
nephrectomy and IVC thrombectomy
0%
No
9 months
excellent status, no signs of recurrence
Litmathe [7]
1989-2000
6
4 CABG, 2 aortic valvuloplasty
5 radical nephrectomy, 1 partial nephrectomy
0%
No
72 months
4 alive, 1 ischemic symptoms
Marino [8]
2008
1
AVR
radical nephrectomy
0%
No
0
No
Dedeilias [9]
2008
1
radical nephrectomy
0%
No
17 months
excellent status, no signs of recurrence
The aim of this report was to prove the possibility of simultaneous difficult cardiac and urologic operation. The most important point of our report concerns the fact that the oncologic treatment was not delayed despite severe heart disease. There is also an advantage in avoiding second operation and hence anesthesia. Essential disadvantages, which have to be considered are as follows: increased probability of bleeding due to heparinization, operation time, its complexity and risk of patient's death.
One-stage cardiac and uro-oncologic operation can be a safe and beneficial procedure, if performed in selected patients by experienced cardiosurgical and urological teams. There is a need of greater number of patients and long term follow-up to establish final conclusions.

Consent

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
References
1.
Hill GE, Whitten CW, Landers DF: The influence of cardiopulmonary bypass on cytokines and cell-cell communication. J Cardiothorac Vasc Anesth 1997, 11: 367–375.PubMedCrossRef
2.
Danton MH, Anikin VA, McManus KG, McGuigan JA, Campalani G: Simultaneous cardiac surgery with pulmonary resection: Presentation of series and review of literature. Eur J Cardiothorac Surg 1998, 13: 667–72.PubMedCrossRef
3.
Evagelopoulos N, Trenz MT, Beckmann A, Krian A: Simultaneous carotid endarterectomy and coronary artery bypass grafting in 313 patients. Cardiovasc Surg 2000, 8: 31–40.PubMedCrossRef
4.
King RC, Parrino PE, Hurst JL, Shockey KS, Tribble MD, Kron ID: Simultaneous coronary artery byppass grafting and abdominal aneurysm repair decreases stay and costs. Ann Thorac Surg 1998, 66: 1273–1276.PubMedCrossRef
5.
Matsuzaki K, Sakai K, Sugawara H, Okamato F, Matano J, Nakanishi K, Narita Y: A case of ascending aortic aneurysm with intrathoracic goiter. Kyobu Geka 2000, 53: 500–502.PubMed
6.
Franke UF, Wahlers T, Wittwer T, Schubert J: Renal carcinoma with caval vein infiltration and triple coronary disease: one-stage surgical management. Eur J Cardiothorac Surg 2001, 20: 877–879.PubMedCrossRef
7.
Litmathe J, Atmaca N, Menghesha D, Krian A: Combined procedures using the extracorporeal circulation and urologic tumor operation - experiences in six cases. Interact Cardiovasc Thorac Surg 2004, 3: 132–135.PubMedCrossRef
8.
Marino G, Di Primio OG, Caputo A, Forsennati P, Flocco R, Casabona R: Cardiovascular and urological combined operation in a patient with severe aortic stenosis and renal cell carcinoma. Minerva Urol Nefrol 2008, 60: 61–64.PubMed
9.
Dedeilias P, Roussakis A, Koletsis EN, Kouerinis I, Balaka C, Apostolakis E, Malovrouvas D: Simultaneous off-pump coronary artery bypass graft and nephrectomy. J Card Surg 2008, 23: 750–3.PubMedCrossRef
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
AAA made substantial contributions to the conception and design of management and report, assisted in the urological part of the operation, analyzed and interpreted all data, and has been involved in drafting the manuscript; SP made substantial contributions to the acquisition of data, analysis and interpretation of data, assisted in the urological part of the operation, and has been involved in drafting the manuscript; ABi made substantial contributions to conception and design, performed the cardiac part of the operation, and has been involved in revising critically the manuscript for important intellectual content; LZ made substantial contributions to acquisition of data and helped in drafting the final version of English text; ABo made substantial contributions to conception and design, performed the urological part of the operation, has been involved in revising critically the manuscript for important intellectual content, and has given final approval of the version to be published. All authors read and approved the final manuscript.