Background

Almost 150 countries on all continents had reported injection drug use by 2007 and 120 of these had reported related HIV infections [1]. According to estimates for 2010–2011, HIV prevalence among the 14–16 million people who inject drugs (PWID) worldwide is 12% with wide variation across regions [2, 3]. Injection drug use is driving HIV epidemics in many countries in Asia, the Middle East, and Eastern Europe and there are continuing epidemics of HIV and other parenterally transmitted viruses such as hepatitis C among PWID in many locations worldwide [4–6]. In many countries, controlling HIV/AIDS and hepatitis epidemics depends on reducing transmission among PWID and other people who use drugs.

For various reasons including widespread stigma and discrimination, people who use drugs are generally underserved by and/or reluctant to visit traditional health providers – physicians, health clinics, and hospitals [7]. In developed countries, many drug users rely on paramedic and/or emergency room care when they are seriously ill, suffer overdose, or experience other health problems. In both developed and developing countries, pharmacies are a type of health facility that is commonly accessed by drug users but their use is often limited to the purchase of needles/syringes and other items related to drug injection [8–10]. Because drug users frequently visit pharmacies there is the potential for pharmacies to provide expanded health services for them [11].

To assess the potential for pharmacies to become venues for expanded health services for PWID, including services related to HIV/AIDS, hepatitis, and substance use prevention and treatment, the National Institute on Drug Abuse, U.S. National Institutes of Health funded linked grants from a consortium of investigators from six sites in four countries – the United States (Boston, Providence, and San Francisco), Russia (St. Petersburg), Vietnam (Ha Giang City), and China (Xichang, Sichuan Province) – to conduct mixed-methods feasibility studies. These sites were selected to provide a range of geographic settings and perceived attitudes towards harm reduction and other services for drug injectors.

The feasibility studies were carried out between 2009 and 2012 with investigators conducting similar studies in Vancouver, Canada and Tijuana, Mexico joining the research group in 2011, bringing the number of countries represented to six and the number of sites to eight. Table 1 presents basic statistics on the epidemics of injection drug use and HIV in these eight sites.

Table 1 Injection drug use, HIV, and research methods in study sites
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The projects aimed to assess current pharmacy services and the potential for their expansion and to identify barriers to and facilitators of such expanded services. These factors included pharmacists’ attitudes and possible interference from law enforcement and policy makers. In this paper, we assess further the feasibility of pharmacies to implement expanded services for PWID based on the legal and policy frameworks of the six countries and other inhibiting and facilitating factors.

Methods

The multi-site feasibility studies of expanded pharmacy services for drug users employed mixed methods: qualitative and quantitative interviews with key stakeholders in health, police, and other sectors, including government officials, health care providers, pharmacists, and PWID, as well as review of relevant legal and policy documents and literature in the field.

The original NIDA grants supported formative study, qualitative interviews, and quantitative surveys in the six original sites. The formative study described the IDU and HIV epidemic situations. Qualitative interviews were then conducted with PWID and key informants from legal, public health, and pharmacy systems and quantitative face-to-face surveys were conducted among PWID and pharmacists. All data collection investigated current HIV and substance abuse services for PWID and the needs for additional services, explored perceptions of pharmacists regarding new services for PWID, and identified barriers to pharmacy participation in health-related interventions for PWID, including possible interference from law enforcement and policy makers. To explore further the enabling environment for potentially expanded pharmacy-based interventions, each site investigator reviewed relevant legal and policy documents and corporate policies of pharmacy chains bearing on the implementation of the expanded services identified in the feasibility studies. The site investigators also provided information from their own knowledge on street-level practices that conform to or contradict the laws and policies of governments and pharmacy chains.

Investigators in the additional sites employed slightly different methods. In Tijuana, information was obtained through focus group discussions and a quantitative survey, as well as review of legal and policy documents. In Vancouver, review of relevant legal and policy documents and ongoing ethnographic and qualitative research by the site investigator were used.

To inform further the analysis of these data, we adapted a conceptual framework based on elements proposed by Rhodes [12, 13] and Burris [14]. This framework consists of three levels, defined as follows:

  • Macro level: Laws and policies governing pharmacy operations and procedures; overall legal framework on drugs and drug paraphernalia; attitudes of the general community;

  • Meso level: Attitudes, policies and practices of pharmacy chains and police agencies; and

  • Micro level: Behavior and attitudes of individual pharmacies/pharmacists, police officers, and people who inject drugs.

Results

The feasibility studies found that the following types of services were most desired by PWID and most likely to be offered by pharmacies in the future: expanded needle/syringe sales and distribution; safe disposal of used needles/syringes; HIV testing; hepatitis B and other vaccinations; methadone maintenance and/or other opioid substitution treatment; provision of naloxone for overdose prevention and rescue; skin abscess prevention and treatment; brief counseling and informational materials; and referrals to HIV/AIDS, substance abuse treatment, and other services.

Table 2 summarizes the government laws and policies in the six countries that are most relevant to each of the proposed expanded services. Table 3 summarizes pharmacy chains’ policies in the sites where such chains exist and information on their policies was available: Boston, Providence, San Francisco, Vancouver, and St. Petersburg.

Table 2 Government laws and policies
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Table 3 Corporate pharmacy policies (chain pharmacies)
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Needle/syringe sales without prescription are legal in all study sites, but several have experienced practical barriers to implementation including attitudes and behaviors of individual pharmacies, even if the law or their chains authorize sales. In Vietnam, a female injector said that

pharmacy sellers should be hospitable, because…IDUs are usually ashamed… If you’re not a hospitable pharmacy seller, then here come a bad IDU [and] he/she could shout at you …--49 year-old ethnic female PWID, injecting for 11 years

In Tijuana, where pharmacy sales of needles/syringes are legal, focus group discussions with PWID revealed that many pharmacies refused to sell needles/syringes due to negative attitudes towards drug users, fear that PWID behavior would drive away other customers, and concern about police response [15]. In a “buy study”, only 28% of attempted purchases by “mystery shoppers” were successful [16]. Tijuana PWID noted the unpredictability and inconsistency of pharmacy sales and the commonly negative attitudes of pharmacy workers:

I mean it can’t be distinguished as one pharmacy or another, the one that does sell to you and the one that doesn’t. You go into the pharmacy and there are times when it does sell to you and others when it doesn’t. – Male focus group participant.

[W]e’re “tecatos”,….we’re junkies and drug addicts, many pharmacies don’t want to sell it to you…. I’ve noticed by how they look at us. –Female focus group participant.

In San Francisco, under a Disease Prevention Demonstration Project (DPDP), participating pharmacies may sell up to 30 needles/syringes at a time but a “buy study”, carried out as part of the feasibility study presented in this paper, revealed inconsistent compliance with program provisions including outright refusals to sell and varying minimum numbers of needles/syringes required for purchase [17].

In St. Petersburg, Russia, a syringe “buy study”, also conducted as part of the pharmacy feasibility study in one central and one peripheral district of the city, found that half of the pharmacies that refused to sell syringes to research staff nonetheless reported in a telephone survey that they stocked syringes [18].

There appear to be no legal barriers to needle/syringe disposal in pharmacies except in St. Petersburg where a special license for such disposal is required, and Ha Giang, Vietnam where disposal of used needles/syringes at pharmacies must comply with the Ministry of Health’s regulations on management of medical wastes (Vietnam Ministry of Health. Decision No. 43/2007/QD-BYT, November 30, 2007). However, individual pharmacies might refuse to offer disposal services. Cost may also play a role in such decisions, as revealed in St. Petersburg:

It [syringe disposal] costs a lot. Not every medical facility can afford waste disposal. --Department Head, drug treatment facility

In San Francisco, some pharmacies’ reluctance to offer required disposal services may explain their refusal to join the DPDP, under which needles/syringes are sold without prescription [17]. In Massachusetts, there is no barrier to pharmacies accepting syringes for disposal, but very few do, citing the high cost and safety concerns with handling medical waste. The Massachusetts Department of Public Health provides disposal “kiosks” but none of these are placed in pharmacies. Biohazardous waste containers and prepaid envelopes to mail used syringes to a biohazardous waste company may be purchased in some pharmacies.

In most sites, HIV testing in pharmacies is not legally barred but cannot be provided without additional staff training or certification. In Tijuana, only saliva-based testing may be done in pharmacies because blood drawing is prohibited. Similarly, St. Petersburg has an explicit prohibition on blood/serum-based HIV testing in pharmacies since this practice is restricted to licensed medical facilities. Oral testing could be conducted at pharmacies in St. Petersburg but individuals testing positive would require confirmatory testing by the Municipal AIDS Center to qualify for care and treatment. In Vancouver, strict requirements for provision of pre/post-test counseling limit the potential for offering HIV testing in pharmacies, although access to testing has recently been expanded through health clinics and community health centers.

In Boston, a recent change in pharmacy regulations permits walk-in clinics to offer adult immunization, including for hepatitis B. With the walk-in clinic infrastructure in place, adding HIV testing may be feasible, but is not currently permitted. Some pharmacy chains operating in San Francisco allow vaccinations but others do not. Several sites, including Boston, San Francisco, Tijuana and Vancouver, require special training or certification for staff to administer vaccinations, while in St. Petersburg pharmacies are prohibited from administering any vaccinations since this requires a medical license and separate space in the facility:

[Vaccination against hepatitis) is impossible [in pharmacies] due to technical reasons. There are numerous regulations that must be met according to the “Sanitary Rules and Norms.” For instance, there must be a separate room with specific technical devices –Deputy Director, drug treatment facility.

Provision of methadone or other OST in pharmacies faces serious legal and practical barriers. A pharmacy worker in Ha Giang, Vietnam noted that

Vietnam Ministry of Health should enact legal documents so we are allowed to sell… it will be troublesome if selling is not permitted. Some specific drugs only university-leveled pharmacists are permitted to sell”. --pharmacy worker in Minh Khai ward

A number of the sites prohibit provision of OST in pharmacies, while in several others special legal dispensation is needed for prescribing methadone or similar medications. In Russia, standard OST is prohibited by law in all facilities. In Vancouver, OST in pharmacies is legally permissible but a substantial proportion of methadone patients attend “private methadone clinics” [19]. In addition, Vancouver physicians must receive an exemption under the Controlled Drugs and Substances Act to prescribe methadone or other medications used in OST.

The provision by pharmacies of naloxone for overdose prevention and rescue also confronts diverse legal and practical challenges. The difficulty or impossibility of PWID getting to pharmacies to receive naloxone while suffering from overdose has prompted the creation of community-based overdose education and naloxone access efforts in some places, designed to increase the likelihood of timely emergency response [20]. Across all sites, naloxone remains a prescription drug, used primarily in clinical settings and by emergency medical staff and police, as recently proposed by New York’s Attorney General [21]. Naloxone is seldom stocked in pharmacies. This inhibits efforts to utilize pharmacies as access points for PWID and their caregivers [22].

In Boston, naloxone could be provided to PWID by pharmacists under the existing “standing order”. This order, issued in 2007 by the medical director of the overdose prevention program, provides that community members and agency workers may be trained to provide nasal naloxone to drug users for overdose prevention. In Providence, naloxone may be provided by pharmacies under collaborative practice agreements with prescribers as part of wider overdose prevention and naloxone access schemes [23]. A collaborative practice agreement is a signed agreement, entered into voluntarily, between a pharmacist with advanced training and experience relevant to the scope of collaborative practice and one or more physicians that defines the collaborative pharmacy practice in which the pharmacist and physician(s) propose to engage.

Many San Francisco pharmacists said that they would routinely fill prescriptions for naloxone. Under California law (SB 767 [2007]), licensed health providers who prescribe and/or distribute naloxone for emergency treatment of drug overdose bear only limited liability. In 2010, this limitation on liability was extended to lay providers of naloxone who have received appropriate training through a program registered by a local health department [http://legiscan.com/CA/text/AB2145/id/60864].

In St. Petersburg, naloxone may be dispensed and administered only in licensed health care facilities. However, naloxone is included in the “List of vitally necessary and the most essential medicinal agents for 2012” (Decree of the Government of RF#2199-r dated of December 7, 2011) which ensures “physical and economical availability” of certain medicinal products. Thus, pharmacies could be compelled to make naloxone available should the appropriate government agencies wish to promote its availability. However, according to one drug treatment professional:

Although it should be legalized, as far as I know, narcologist cannot prescribe naloxone to a drug addict. …There is no indication in the labeling for naloxone that would allow it to be used for overdose prevention outside the clinical setting. It says that [the] medication is to be used in medical facilities by a physician. –Department Head, drug treatment facility

According to laws or regulations in most sites, pharmacists cannot clean or dress abscesses because this would constitute a practice of medicine prohibited to them. In some countries, as well, providing such care could also raise medical malpractice issues. However, in most sites pharmacists could dispense antibiotics or ointments for treatment of abscesses, with or without a prescription depending on the country. In San Francisco, abscess treatment in pharmacies may not be authorized by relevant government agencies because such services are already available at clinics and hospitals.

There are few if any legal or policy barriers to pharmacies providing information, materials, brief counseling and referrals on any health issues, including HIV/AIDS, hepatitis, abscess treatment, overdose prevention and rescue, and substance abuse treatment. The challenges that exist arise largely from the practices and attitudes of individual pharmacies and their staffs. In San Francisco, the needle/syringe “buy study” found that many pharmacies participating in the DPDP were not providing written or oral information on substance abuse treatment, HIV/HCV testing, and safe disposal of used needles/syringes that is required to accompany each needle/syringe sale [17].

Discussion

This review of laws, policies, and practices presents a mixed picture of the possibilities for implementing pharmacy-based service enhancements for drug users. Provision of informational materials and referrals in pharmacies is legally permissible in all study sites and sale and safe disposal of needles/syringes by pharmacies is legal in almost all sites. Pharmacy provision of other services identified as most promising in the study, such as HIV testing, hepatitis and other vaccinations, opioid substitution treatment, provision of naloxone for treatment of opioid overdose, and abscess treatment face more serious and pervasive legal and policy barriers.

We identified challenges to achieving a truly enabling environment for the implementation of expanded pharmacy services at all three levels of our conceptual model. The most commonly identified challenges occur at the macro-level where legal and policy provisions block provision of some services and medications in pharmacies and persistent stigma and its internalization by PWID reduce uptake of services that do exist. Lack of relationships between pharmacies and HIV prevention and addiction-related resources in the community and consequent lack of consensus as to who should provide specific HIV-related services also represent barriers to expansion of services in pharmacies. In places dominated by private chain pharmacies, skepticism that providing additional services for PWID would translate into increased pharmacy profits have also hindered offering such services.

At the meso-level, our study uncovered variations in policy and practice related to services for PWID across police agencies and pharmacy chains. For example, some pharmacy chains narrowly define pharmacists’ roles and responsibilities and limit interventions. Lack of sufficient time and appropriate space may also limit possibilities for expansion of services in pharmacies.

At the micro-level, differences in knowledge (such as lack of understanding of addiction and harm reduction), attitudes (such as stigmatizing PWID customers), and behaviors (such as refusal to sell needles/syringes to suspected PWID) of individuals pharmacists, pharmacy workers, shift managers in large pharmacies, police officers, and other actors pose barriers to the expansion of pharmacy-based services for PWID. In Russia, for example, all aspects of life are highly bureaucratized and officials and pharmacists feel that they must comply with all regulations or risk punishment and damage to their careers. They may also use the existence of prohibitory rules and regulations to rationalize the denial of services that they know or suspect would advance public health.

At the macro- level, where deficiencies and barriers in governmental laws and policies may block implementation, stakeholders should advocate with relevant government bodies for the needed legal and policy changes. For example, in Russia, PWID access to sterile injection equipment could be increased by inclusion of syringes in the federal list of mandatory medical products sold by pharmacies [18]. Arguments from public health and safety are likely to be the most persuasive and evidence should be marshaled from places that have successfully and effectively expanded pharmacy services such as needle/syringe sales.

Community-level stigma, discrimination, and resistance to harm reduction interventions also inhibit PWID’s access to all kinds of health services. Efforts are needed to convince community members that those suffering from drug addiction, a medical and psychosocial problem, would benefit from services delivered in a respectful and non-discriminatory manner and that such services contribute importantly to disease prevention without encouraging drug use.

In areas for potential expansion of pharmacy services in which there has been little success to date, such as vaccination, MMT/OST, and naloxone provision, stakeholders should assess the local situation and determine the importance of pharmacies providing these services before undertaking the difficult work needed to achieve the changes in the legal and policy framework that would be required. Laws limiting the liability of pharmacists who prescribe naloxone to treat opioid overdose were adopted in Massachusetts and Rhode Island since the completion of our study. There are also efforts underway to make naloxone available over the counter in the United States, but this would require approval of the Food and Drug Administration [http://drugtopics.modernmedicine.com/news/otc-naloxone-its-possible].

Advocates should consider multiple stakeholder viewpoints when designing policy reform efforts, including possible incentive mechanisms to engage pharmacies and other healthcare providers in services for drug users. No legal or policy changes appear to be necessary to allow expanded provision of counseling, informational materials, and referrals but structural changes such as provision of insurance coverage to compensate pharmacists for counseling or brief interventions may be needed to assure acceptability and sustainability of interventions [24, 25].

Attention is also needed at the meso- and micro- levels. Laws and policies are only as good as their implementation. Serious gaps in the implementation of needle/syringe programs are well-documented and especially problematic in settings with weak rule of law [26–29]. Police department and pharmacy chain policies, and the knowledge, attitudes, and practices of individual PWID, individual pharmacies/pharmacists, and police officers should support rather than undermine extant laws and policies. Pharmacists’ attitudes and practices have been shown to influence provision of needles/syringes, opioid substitution treatment, counseling, and dissemination of HIV prevention and other health promotion materials to PWID in Scotland [30], Australia [31, 32], and Estonia [9].

Training for pharmacists and police officers could be conducted to promote more supportive attitudes towards proposed programs [28, 30, 33]. Systematic monitoring of police abuse of drug users around pharmacies and other service points may also help address structural barriers to service access [34]. Programs are also needed to increase the self-efficacy of PWID to improve their relationships with pharmacists and thereby facilitate access to expanded services.

Overall, a considerable amount of advocacy will be needed if pharmacies are to reach their potential as venues for delivering services to drug users. This advocacy should employ a public health perspective, demonstrate cost-effectiveness of harm reduction interventions, and promote a human rights approach to the health problems of marginalized populations.