Research article

BMC Cancer

, 13:28

Open Access This content is freely available online to anyone, anywhere at any time.

Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

  • Linda E KelemenAffiliated withDepartment of Population Health Research, Alberta Health Services-Cancer Care and Departments of Medical Genetics and Oncology, University of Calgary Email author 
  • , Elisa V BanderaAffiliated withThe Cancer Institute of New Jersey, Robert Wood Johnson Medical School
  • , Kathryn L TerryAffiliated withObstetrics and Gynecology Epidemiology Center, Brigham and Women’s HospitalDepartment of Epidemiology, Harvard School of Public Health
  • , Mary Anne RossingAffiliated withFred Hutchinson Cancer Research Center
  • , Louise A BrintonAffiliated withDivision of Cancer Epidemiology and Genetics, National Cancer Institute
  • , Jennifer A DohertyAffiliated withFred Hutchinson Cancer Research Center
  • , Roberta B NessAffiliated withUniversity of Texas School of Public Health
  • , Susanne Krüger KjærAffiliated withDanish Cancer Society Research CenterGynecologic Clinic, Rigshospitalet, University of Copenhagen
  • , Jenny Chang-ClaudeAffiliated withDivision of Cancer Epidemiology, German Cancer Research Center
    • , Martin KöbelAffiliated withDepartment of Pathology and Laboratory Medicine, Calgary Laboratory Services
    • , Galina LurieAffiliated withCancer Research Center, University of Hawaii
    • , Pamela J ThompsonAffiliated withCancer Research Center, University of Hawaii
    • , Michael E CarneyAffiliated withCancer Research Center, University of Hawaii
    • , Kirsten MoysichAffiliated withRoswell Park Cancer Center
    • , Robert EdwardsAffiliated withMagee Womens Research Institute
    • , Clare BunkerAffiliated withUniversity of Pittsburgh School of Public Health
    • , Allan JensenAffiliated withDanish Cancer Society Research Center
    • , Estrid HøgdallAffiliated withDanish Cancer Society Research Center
    • , Daniel W CramerAffiliated withObstetrics and Gynecology Epidemiology Center, Brigham and Women’s HospitalDepartment of Epidemiology, Harvard School of Public Health
    • , Allison F VitonisAffiliated withObstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital
    • , Sara H OlsonAffiliated withMemorial Sloan-Kettering Cancer Center
    • , Melony KingAffiliated withThe Cancer Institute of New Jersey, Robert Wood Johnson Medical School
    • , Urmila ChandranAffiliated withThe Cancer Institute of New Jersey, Robert Wood Johnson Medical School
    • , Jolanta LissowskaAffiliated withDepartment of Cancer Epidemiology and Prevention, The M. Sklodowska-Curie Cancer Center and Institute of Oncology
    • , Montserrat Garcia-ClosasAffiliated withDivision of Genetics and Epidemiology, Institute of Cancer Research
    • , Hannah YangAffiliated withDivision of Cancer Epidemiology and Genetics, National Cancer Institute
    • , Penelope M WebbAffiliated withThe Queensland Institute of Medical Research, Locked Bag 2000 Royal Brisbane Hospital
    • , Joellen M SchildkrautAffiliated withDepartment of Community and Family Medicine and the Comprehensive Cancer Center, Duke University Medical Center
    • , Marc T GoodmanAffiliated withCancer Research Center, University of HawaiiDepartments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center
    • , Harvey A RischAffiliated withDepartment of Chronic Disease Epidemiology, Yale School of Public Health
    • , , on behalf of the Australian Ovarian Cancer Study Group and Australian Cancer Study (Ovarian Cancer)
    • , and on behalf of the Ovarian Cancer Association Consortium

Abstract

Background

Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.

Methods

We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.

Results

Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.

Conclusions

We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.