, 1:P76,
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Date: 16 Nov 2012

A central role for Galectin 3 during renal epithelial cell morphogenesis after nephrectomy

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Galectin-3, a member of the multigene family of beta-galactoside binding lectins, is mainly expressed in epithelial cells. The distribution of galectin-3 depends on cell type and cell differentiation. We previously showed that galectin-3 is transiently associated with the centrosome, and more specifically with the basal body at the basis of the primary cilium of MDCK cells. In the present study, we use galectin-3 null (Gal3-/-) mutant mice to investigate the functional consequences of our observations in the context of kidney regeneration after subtotal nephrectomy. Three months after surgery, renal functions were more severely affected in Gal3-/- mutant than in wt animals. Upon sacrifice, we found that Gal3-/- mutant kidneys were bigger and heavier, and this hypertrophy was associated with large tubular dilatations. Interestingly, in wt mice, galectin 3 intracellular distribution was altered in response to injury, displaying a distinct centrosomal localization in epithelial cells lini ...