The transition zone: an essential functional compartment of cilia
- Katarzyna SzymanskaAffiliated withSection of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, St. James’s University Hospital
- , Colin A JohnsonAffiliated withSection of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, St. James’s University Hospital Email author
Recent studies of the primary cilium have begun to provide further insights into ciliary ultrastructure, with an emerging picture of complex compartmentalization and molecular components that combine in functional modules. Many proteins that are mutated in ciliopathies are localized to the transition zone, a compartment of the proximal region of the cilium. The loss of these components can disrupt ciliary functions such as the control of protein entry and exit from the cilium, the possible trafficking of essential ciliary components, and the regulation of signaling cascades and control of the cell cycle. The discovery of functional modules within the primary cilium may help in understanding the variable phenotypes and pleiotropy in ciliopathies.
KeywordsCilia Transition zone IFT Ciliopathies
- The transition zone: an essential functional compartment of cilia
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Online Date
- July 2012
- Online ISSN
- BioMed Central
- Additional Links
- Transition zone