, 3:11,
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Date: 18 May 2012

Editors’ Pick: Normal aging versus Alzheimer’s disease – expression patterns may discern the differences

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“The Times They Are a-Changin’,” one of Bob Dylan’s albums of the 1960’s, reflected the social change of the time. These same words reflect science today as it has and continues to change, providing advances that once would have been thought to be impossible or would require monumental efforts as applied to the human genome project. These tools will have a tremendous impact on society and individuals with a promise of improving the quality of life. An example of the possibilities that the wave of molecular biology advances affords is the recent publication by Podtelezhnikov et al.[1]. They show convincingly the value of the technology of expression arrays for studying pathways of complex diseases, such as Alzheimer’s disease (AD), that may affect many of us, either directly or indirectly, through a family member or friend.

Podtelezhnikov et al.[1] investigated global structure of age- and disease-dependent gene expression patterns in three brain regions from 600 individuals. The bra