Testing for amphetamine-type stimulant (ATS) use to ascertain validity of self-reported ATS use among young female sex workers in Cambodia
To assess concordance between self-reported amphetamine-type stimulant (ATS) use and toxicology results among young female sex workers (FSW) in Phnom Penh, Cambodia.
Cross-sectional data from the Young Women’s Health Study-2 (YWHS-2), a prospective study of HIV and ATS use among young (15 to 29 years) FSW in Phnom Penh, Cambodia, was analyzed. The YWHS-2 assessed sociodemographic characteristics, HIV serology, HIV risk, and ATS use by self-report and urine toxicology testing at each quarterly visit, the second of which provided data for this assessment. Outcomes include sensitivity, specificity, positive- and negative predictive values (overall and stratified by age), sex-work setting, and HIV status.
Among 200 women, prevalence of positive toxicology screening for ATS use was 14% (95% confidence interval [CI], 9.2, 18.9%) and concurrent prevalence of self-reported ATS was 15.5% (95% CI, 10.4, 20.6%). The sensitivity and specificity of self-reported ATS use compared to positive toxicology test results was 89.3% (25/28), and 96.5% (166/172), respectively. The positive predictive value of self-reported ATS use was 80.6% (25/31); the negative predictive value was 98.2% (166/169). Some differences in concordance between self-report and urine toxicology results were noted in analyses stratified by age group and sex-work setting but not by HIV status.
Results indicate a high prevalence of ATS use among FSW in Phnom Penh, Cambodia, and high concordance between self-reported and toxicology-test confirmed ATS use.
- Mills, E, Singh, S, Orbinski, J, Burrows, D (2005) The HIV/AIDS epidemic in Cambodia. Lancet Infect Dis 5: pp. 596-597 CrossRef
- Ministry of Health National Center for HIV, AIDS, Dermatology and STDs.
- Couture, MC, Sansothy, N, Sapphon, V, Phal, S, Sichan, K, Stein, E, Evans, J, Maher, L, Kaldor, J, Vun, MC (2010) Young women engaged in sex work in Phnom Penh, Cambodia, have high incidence of HIV and sexually transmitted infections, and amphetamine-type stimulant use: new challenges to HIV prevention and risk. Sex Transm Dis 38: pp. 33-39
- Sopheab, H, Morineau, G, Neal, JJ, Saphonn, V, Fylkesnes, K (2008) Sustained high prevalence of sexually transmitted infections among female sex workers in Cambodia: high turnover seriously challenges the 100 % Condom Use Programme. BMC Infect Dis 8: pp. 167 CrossRef
- Sopheab, H, Saphonn, V, Chhea, C, Fylkesnes, K (2009) Distribution of HIV in Cambodia: findings from the first national population survey. AIDS 23: pp. 1389-1395 CrossRef
- Charles, M (2006) HIV epidemic in Cambodia, one of the poorest countries in Southeast Asia: a success story. Expert Rev Anti Infect Ther 4: pp. 1-4 CrossRef
- World Health Organization Regional Office for the Western Pacific: Controlling STI and HIV in Cambodia: The success of condom promotion. [http://wwwwhoint/hiv/topics/vct/sw_toolkit/controlling_sti_campdf].
- Sopheab, H, Fylkesnes, K, Vun, MC, O'Farrell, N (2006) HIV-related risk behaviors in Cambodia and effects of mobility. J Acquir Immune Defic Syndr 41: pp. 81-86 CrossRef
- Couture, MC, Evans, JL, Sothy, NS, Stein, ES, Sichan, K, Maher, L, Page, K (2012) Correlates of amphetamine-type stimulant use and associations with HIV-related risks among young women engaged in sex work in Phnom Penh, Cambodia. Drug Alcohol Depend 120: pp. 119-126 CrossRef
- Maher, L, Phlong, P, Mooney-Somers, J, Keo, S, Stein, E, Couture, MC, Page, K (2011) Amphetamine-type stimulant use and HIV/STI risk behaviour among young female sex workers in Phnom Penh, Cambodia. Int J Drug Policy 22: pp. 203-209 CrossRef
- Barr, AM, Panenka, WJ, MacEwan, GW, Thornton, AE, Lang, DJ, Honer, WG, Lecomte, T (2006) The need for speed: an update on methamphetamine addiction. J Psychiatry Neurosci 31: pp. 301-313
- McKetin, R, Kozel, N, Douglas, J, Ali, R, Vicknasingam, B, Lund, J, Li, JH (2008) The rise of methamphetamine in Southeast and East Asia. Drug Alcohol Rev 27: pp. 220-228 CrossRef
- Boddiger, D (2005) Metamphetamine use linked to rising HIV transmission. Lancet 365: pp. 1217-1218 CrossRef
- Buavirat, A, Page-Shafer, K, van Griensven, GJ, Mandel, JS, Evans, J, Chuaratanaphong, J, Chiamwongpat, S, Sacks, R, Moss, A (2003) Risk of prevalent HIV infection associated with incarceration among injecting drug users in Bangkok, Thailand: case–control study. BMJ 326: pp. 308 CrossRef
- Cheng, WS, Garfein, RS, Semple, SJ, Strathdee, SA, Zians, JK, Patterson, TL (2009) Differences in sexual risk behaviors among male and female HIV-seronegative heterosexual methamphetamine users. Am J Drug Alcohol Abuse 35: pp. 295-300 CrossRef
- Cheng, WS, Garfein, RS, Semple, SJ, Strathdee, SA, Zians, JK, Patterson, TL (2010) Increased drug use and STI risk with injection drug use among HIV-seronegative heterosexual methamphetamine users. J Psychoactive Drugs 42: pp. 11-18 CrossRef
- Colfax, G, Shoptaw, S (2005) The methamphetamine epidemic: implications for HIV prevention and treatment. Curr HIV/AIDS Rep 2: pp. 194-199 CrossRef
- Molitor, F, Ruiz, JD, Flynn, N, Mikanda, JN, Sun, RK, Anderson, R (1999) Methamphetamine use and sexual and injection risk behaviors among out-of-treatment injection drug users. Am J Drug Alcohol Abuse 25: pp. 475-493 CrossRef
- Wohl, AR, Johnson, DF, Lu, S, Jordan, W, Beall, G, Currier, J, Simon, PA (2002) HIV risk behaviors among African American men in Los Angeles County who self-identify as heterosexual. J Acquir Immune Defic Syndr 31: pp. 354-360 CrossRef
- Patterns and Trends of Amphetamine-Type Stimulants and Other Drugs: Asia and the Pacific.
- Report on Illicit Drug Data and Routine Surveillance Systems.
- Dillon, FR, Turner, CW, Robbins, MS, Szapocznik, J (2005) Concordance among biological, interview, and self-report measures of drug use among African American and Hispanic adolescents referred for drug abuse treatment. Psychol Addict Behav 19: pp. 404-413 CrossRef
- De Irala, J, Bigelow, C, McCusker, J, Hindin, R, Zheng, L (1996) Reliability of self-reported human immunodeficiency virus risk behaviors in a residential drug treatment population. Am J Epidemiol 143: pp. 725-732 CrossRef
- Latkin, CA, Vlahov, D, Anthony, JC (1993) Socially desirable responding and self-reported HIV infection risk behaviors among intravenous drug users. Addiction 88: pp. 517-526 CrossRef
- Des Jarlais, DC, Paone, D, Milliken, J, Turner, CF, Miller, H, Gribble, J, Shi, Q, Hagan, H, Friedman, SR (1999) Audio-computer interviewing to measure risk behaviour for HIV among injecting drug users: a quasi-randomised trial. Lancet 353: pp. 1657-1661 CrossRef
- Metzger, DS, Koblin, B, Turner, C, Navaline, H, Valenti, F, Holte, S, Gross, M, Sheon, A, Miller, H, Cooley, P (2000) Randomized controlled trial of audio computer-assisted self-interviewing: utility and acceptability in longitudinal studies. HIVNET Vaccine Preparedness Study Protocol Team. Am J Epidemiol 152: pp. 99-106
- Harrison, L (1997) The validity of self-reported drug use in survey research: an overview and critique of research methods. NIDA Res Monogr 167: pp. 17-36
- Fendrich, M, Johnson, TP (2005) Race/ethnicity differences in the validity of self-reported drug use: results from a household survey. J Urban Health 82: pp. iii67-iii81 CrossRef
- Fendrich, M, Xu, Y (1994) The validity of drug use reports from juvenile arrestees. Int J Addict 29: pp. 971-985
- Rosay, AB, Najaka, SS, Herz, D (2007) Differences in the validity of self-reported drug use across five factors: gender, race, age, type of drug, and offense seriousness. J of Quantitative Criminology 23: pp. 41-58 CrossRef
- Sherman, MF, Bigelow, GE (1992) Validity of patients' self-reported drug use as a function of treatment status. Drug Alcohol Depend 30: pp. 1-11 CrossRef
- Elman, I, Krause, S, Breiter, HC, Gollub, RL, Heintges, J, Baumgartner, WA, Rosen, BR, Gastfriend, DR (2000) The validity of self-reported drug use in non-treatment seeking individuals with cocaine dependence: correlation with biochemical assays. Am J Addict 9: pp. 216-221 CrossRef
- Weatherby, NL, Needle, R, Cesari, H, Booth, R, McCoy, CB, Watters, JK, Williams, M, Chitwood, DD (1994) Validity of self-reported drug use among injection drug users and crack cocaine users recruited through street outreach. Eval Program Plann 17: pp. 347-355 CrossRef
- Hser, YI, Maglione, M, Boyle, K (1999) Validity of self-report of drug use among STD patients, ER patients, and arrestees. Am J Drug Alcohol Abuse 25: pp. 81-91 CrossRef
- Magura, S, Kang, SY (1996) Validity of self-reported drug use in high risk populations: a meta-analytical review. Subst Use Misuse 31: pp. 1131-1153 CrossRef
- Hser, YI (1997) Self-reported drug use: results of selected empirical investigations of validity. NIDA Res Monogr 167: pp. 320-343
- Cook, RF, Bernstein, AD, Andrews, CM (1997) Assessing drug use in the workplace: a comparison of self-report, urinalysis, and hair analysis. NIDA Res Monogr 167: pp. 247-272
- Zanis, DA, McLellan, AT, Randall, M (1994) Can you trust patient self-reports of drug use during treatment?. Drug Alcohol Depend 35: pp. 127-132 CrossRef
- Harrison, L (1995) The validity of self-reported data on drug use. Journal of Drug Issues 25: pp. 91-111
- Williams, RJ, Nowatzki, N (2005) Validity of adolescent self-report of substance use. Subst Use Misuse 40: pp. 299-311 CrossRef
- Cook, RF, Bernstein, AD, Arrington, TL, Andrews, CM, Marshall, GA (1995) Methods for assessing drug use prevalence in the workplace: a comparison of self-report, urinalysis, and hair analysis. Int J Addict 30: pp. 403-426
- Prendergast, M, Podus, D, Finney, J, Greenwell, L, Roll, J (2006) Contingency management for treatment of substance use disorders: a meta-analysis. Addiction 101: pp. 1546-1560 CrossRef
- Lee, NK, Rawson, RA (2008) A systematic review of cognitive and behavioural therapies for methamphetamine dependence. Drug Alcohol Rev 27: pp. 309-317 CrossRef
- Rawson, RA, Gonzales, R, Brethen, P (2002) Treatment of methamphetamine use disorders: an update. J Subst Abuse Treat 23: pp. 145-150 CrossRef
- Rawson, RA, Gonzales, R, Marinelli-Casey, P, Ang, A (2007) Methamphetamine dependence: a closer look at treatment response and clinical characteristics associated with route of administration in outpatient treatment. Am J Addict 16: pp. 291-299 CrossRef
- Shoptaw, S, Klausner, JD, Reback, CJ, Tierney, S, Stansell, J, Hare, CB, Gibson, S, Siever, M, King, WD, Kao, U (2006) A public health response to the methamphetamine epidemic: the implementation of contingency management to treat methamphetamine dependence. BMC Publ Health 6: pp. 214 CrossRef
- Colfax, GN, Santos, GM, Das, M, Santos, DM, Matheson, T, Gasper, J, Shoptaw, S, Vittinghoff, E (2011) Mirtazapine to reduce methamphetamine use: a randomized controlled trial. Arch Gen Psychiatry 68: pp. 1168-1175 CrossRef
- Testing for amphetamine-type stimulant (ATS) use to ascertain validity of self-reported ATS use among young female sex workers in Cambodia
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- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Addiction Science & Clinical Practice
- Online Date
- June 2012
- Online ISSN
- BioMed Central
- Additional Links
- Author Affiliations
- 1. School of Public Health, University of California at Berkeley, Berkeley, California, USA
- 2. Department of Epidemiology and Biostatistics, University of California San Francisco, 50 Beale Street, Ste 1200, San Francisco, CA, 94105, USA
- 3. Cambodia National Center for HIV, AIDS, Dermatology and STDs, Phnom Penh, Cambodia
- 4. The Kirby Institute (formerly the National Centre in HIV Epidemiology and Clinical Research), Sydney, New South Wales, Australia