Long-term alterations of striatal parvalbumin interneurons in a rat model of early exposure to alcohol
- Andrea De GiorgioAffiliated withDepartment of Psychology, Catholic University
- , Sara E CompariniAffiliated withDepartment of Psychology, Catholic University
- , Francesca Sangiuliano IntraAffiliated withDepartment of Psychology, Catholic University
- , Alberto GranatoAffiliated withDepartment of Psychology, Catholic University Email author
Exposure to alcohol in utero is a known cause of mental retardation. Although a certain degree of motor impairment is always associated with fetal alcohol spectrum disorder, little is known about the neurobiological basis of the defective motor control. We have studied the striatal interneurons containing parvalbumin in a rat model of fetal alcohol spectrum disorder.
Newborn rats received ethanol by inhalation from postnatal day two through six and parvalbumin striatal neurons were labeled by immunohistochemistry on postnatal day 60. The spatial distribution of parvalbumin interneurons was studied using Voronoi spatial tessellation and their dendritic trees were completely reconstructed.
Parvalbumin interneurons of ethanol-treated animals showed a clustered spatial distribution similar to that observed in control animals. The dendritic tree of parvalbumin interneurons was significantly reduced in ethanol-treated animals, as compared with controls.
Striatal parvalbumin interneurons are crucial components of the brain network serving motor control. Therefore, the shrinkage of their dendrites could contribute to the motor and cognitive symptoms observed in fetal alcohol spectrum disorder.
KeywordsFetal alcohol GABA Interneuron Parvalbumin Striatum Voronoi tessellation
- Long-term alterations of striatal parvalbumin interneurons in a rat model of early exposure to alcohol
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Journal of Neurodevelopmental Disorders
- Online Date
- July 2012
- Print ISSN
- Online ISSN
- BioMed Central
- Additional Links
- Fetal alcohol
- Voronoi tessellation