Metastatic pituitary carcinoma in a patient with acromegaly: a case report
- Seamus SreenanAffiliated withDepartment of Endocrinology, Connolly HospitalThe Royal College of Surgeons in Ireland
- , Elizabeth SenguptaAffiliated withDepartment of Pathology, University of Chicago, Medical Center
- , William TormeyAffiliated withDepartment of Chemical Pathology, Connolly HospitalUniversity of Ulster at Coleraine Email author
- , Richard LandauAffiliated withDepartment of Endocrinology, University of Chicago Medical Center
Asymptomatic pituitary abnormalities occur in about 10% of cranial magnetic resonance imaging scans, but metastatic carcinoma of the pituitary gland is rare: 133 cases have been reported. Two thirds secreted either prolactin or adrenocorticotropic hormone, and another 24% were non-secreting.
A 42-year-old Caucasian man lived for 30 years after the diagnosis of a pituitary tumor whose clinical and biochemical features were those of acromegaly and hypogonadism. Radiotherapy, totaling 7300 rad, was administered to the sella over two courses. Growth hormone levels normalized, but he developed both thyroid and adrenal insufficiency, and replacement therapy was commenced. Fourteen years later, growth hormone levels again became elevated, and bromocriptine was commenced but led to side effects that could not be tolerated. An attempted surgical intervention failed, and octreotide and pergolide were used in succession. Twenty-seven years after the diagnosis, a mass from an excisional biopsy of below the angle of the mandible proved to be metastatic pituitary carcinoma. Immunohistochemical staining was positive for synaptophysin, growth hormone, and prolactin. One year later, an octreotide scan showed uptake at the sella, neck, and spleen. Our patient declined further active oncology treatment.
Metastatic pituitary carcinoma associated with acromegaly is particularly rare. To the best of our knowledge, this is the eighth such case and is the first report of growth hormone and prolactin present in the metastatic mass.
KeywordsMetastatic pituitary carcinoma Acromegaly
- Metastatic pituitary carcinoma in a patient with acromegaly: a case report
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Journal of Medical Case Reports
- Online Date
- September 2012
- Online ISSN
- BioMed Central
- Additional Links
- Metastatic pituitary carcinoma
- Author Affiliations
- 1. Department of Endocrinology, Connolly Hospital, Dublin 15, Ireland
- 2. The Royal College of Surgeons in Ireland, Dublin 2, Ireland
- 3. Department of Pathology, University of Chicago, Medical Center, Chicago, IL, USA
- 4. Department of Chemical Pathology, Connolly Hospital, Dublin 15, Ireland
- 5. University of Ulster at Coleraine, Coleraine, Northern Ireland
- 6. Department of Endocrinology, University of Chicago Medical Center, Chicago, IL, USA