Prostate carcinoma metastatic to the skin as an extrammamary Paget’s disease
- Eugen Bogdan PetcuAffiliated withGriffith University School of Medicine, Griffith UniversityDepartment of Anatomy and Doctoral School, University of Medicine and Pharmacy Targu Mures Email author
- , Aldo Gonzalez-ServaAffiliated withDepartment of Pathology, Winchester Hospital
- , Robert G WrightAffiliated withDepartment of Pathology, Gold Coast University Hospital
- , Mark SlevinAffiliated withAngiogenesis and Vascular Biology Group, Manchester Metropolitan University
- , Klara BrinzaniucAffiliated withDepartment of Anatomy and Doctoral School, University of Medicine and Pharmacy Targu Mures
The current paper describes a case of prostatic adenocarcinoma metastatic to the skin presenting as an extrammamary Paget's disease, a very rare and poorly characterised morphological entity. We report a case of prostatic carcinoma metastatic to skin showing a pattern of extramammary Paget's disease which has not been clearly illustrated in the literature Case presentation: A 63 year-old man with prostatic adenocarcinoma developed cutaneous metastases after 16 years. The inguinal metastases were sessile and 'keratotic.' The tumour displayed solid, glandular areas as well as a polypoid region suggestive of extramammary Paget's disease were identified.
Discussion and conclusions
We review the diagnostic criteria that have led to the correct histopathological diagnosis in this case. A differential diagnosis of the pagetoid spread in the skin and various forms of cutaneous metastases determined by a prostatic adenocarcinoma as well as the role of immunohistochemistry in establishing the prostatic origin are presented in the context of this case. Although, morphologically the cells presented in the skin deposits were not characteristic for adenocarcinoma of prostate, immunohistochemistry for PSA and PSAP suggested a prostatic origin.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1395450057455276
- Prostate carcinoma metastatic to the skin as an extrammamary Paget’s disease
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Online Date
- August 2012
- Online ISSN
- BioMed Central
- Additional Links
- Author Affiliations
- 1. Griffith University School of Medicine, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia
- 5. Department of Anatomy and Doctoral School, University of Medicine and Pharmacy Targu Mures, Targu Mures, 540000, Romania
- 2. Department of Pathology, Winchester Hospital, Winchester, MA, 01890, USA
- 3. Department of Pathology, Gold Coast University Hospital, Southport, QLD, 4215, Australia
- 4. Angiogenesis and Vascular Biology Group, Manchester Metropolitan University, Manchester, UK