Particulate matter (PM) 2.5 levels in ETS emissions of a Marlboro Red cigarette in comparison to the 3R4F reference cigarette under open- and closed-door condition
Potential health damage by environmental emission of tobacco smoke (environmental tobacco smoke, ETS) has been demonstrated convincingly in numerous studies. People, especially children, are still exposed to ETS in the small space of private cars. Although major amounts of toxic compounds from ETS are likely transported into the distal lung via particulate matter (PM), few studies have quantified the amount of PM in ETS.
The aim of this study was to determine the ETS-dependent concentration of PM from both a 3R4F reference cigarette (RC) as well as a Marlboro Red brand cigarette (MRC) in a small enclosed space under different conditions of ventilation to model car exposure.
In order to create ETS reproducibly, an emitter (ETSE) was constructed and mounted on to an outdoor telephone booth with an inner volume of 1.75 m3. Cigarettes were smoked under open- and closed-door condition to imitate different ventilation scenarios. PM2.5 concentration was quantified by a laser aerosol spectrometer (Grimm; Model 1.109), and data were adjusted for baseline values. Simultaneously indoor and outdoor climate parameters were recorded. The time of smoking was divided into the ETS generation phase (subset “emission”) and a declining phase of PM concentration (subset “elimination”); measurement was terminated after 10 min. For all three time periods the average concentration of PM2.5 (Cmean-PM2.5) and the area under the PM2.5 concentration curve (AUC-PM2.5) was calculated. The maximum concentration (Cmax-PM2.5) was taken from the total interval.
For both cigarette types open-door ventilation reduced the AUC-PM2.5 (RC: from 59 400 ± 14 600 to 5 550 ± 3 900 μg*sec/m3; MRC: from 86 500 ± 32 000 to 7 300 ± 2 400 μg*sec/m3; p < 0.001) and Cmean-PM2.5 (RC: from 600 ± 150 to 56 ± 40 μg/m3, MRC from 870 ± 320 to 75 ± 25 μg/m3; p < 0.001) by about 90%. Cmax-PM2.5 was reduced by about 80% (RC: from 1 050 ± 230 to 185 ± 125 μg/m3; MRC: from 1 560 ±500 μg/m3 to 250 ± 85 μg/m3; p < 0.001). In the subset “emission” we identified a 78% decrease in AUC-PM2.5 (RC: from 18 600 ± 4 600 to 4 000 ± 2 600 μg*sec/m3; MRC: from 26 600 ± 7 200 to 5 800 ± 1 700 μg*sec/m3; p < 0.001) and Cmean-PM2.5 (RC: from 430 ± 108 to 93 ± 60 μg/m3; MRC: from 620 ± 170 to 134 ± 40 μg/m3; p < 0.001). In the subset “elimination” we found a reduction of about 96–98% for AUC-PM2.5 (RC: from 40 800 ± 11 100 to 1 500 ± 1 700 μg*sec/m3; MRC: from 58 500 ± 25 200 to 1 400 ± 800 μg*sec/m3; p < 0.001) and Cmean-PM2.5 (RC: from 730 ± 200 to 27 ± 29 μg/m3; MRC: from 1 000 ± 450 to 26 ± 15 μg/m3; p < 0.001). Throughout the total interval Cmax-PM2.5 of MRC was about 50% higher (1 550 ± 500 μg/m3) compared to RC (1 050 ± 230 μg/m3; p < 0.05). For the subset “emission” - but not for the other periods - AUC-PM2.5 for MRC was 43% higher (MRC: 26 600 ± 7 200 μg*sec/m3; RC: 18 600 ± 4 600 μg*sec/m3; p < 0.05) and 44% higher for Cmean-PM2.5 (MRC: 620 ± 170 μg/m3; RC: 430 ± 108 μg/m3; p < 0.05).
This method allows reliable quantification of PM2.5-ETS exposure under various conditions, and may be useful for ETS risk assessment in realistic exposure situations. The findings demonstrate that open-door condition does not completely remove ETS from a defined indoor space of 1.75 m3. Because there is no safe level of ETS exposure ventilation is not adequate enough to prevent ETS exposure in confined spaces, e.g. private cars. Additionally, differences in the characteristics of cigarettes affect the amount of ETS particle emission and need to be clarified by ongoing investigations.
- Criteria used in establishing guideline values. Book Criteria used in establishing guideline values. vol. 2.
- Klepeis, NE, Nelson, WC, Ott, WR, Robinson, JP, Tsang, AM, Switzer, P, Behar, JV, Hern, SC, Engelmann, WH (2001) The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. J Expo Anal Environ Epidemiol 11: pp. 231-252 CrossRef
- Simoni, M, Scognamiglio, A, Carrozzi, L, Baldacci, S, Angino, A, Pistelli, F, Di Pede, F, Viegi, G (2004) Indoor exposures and acute respiratory effects in two general population samples from a rural and an urban area in Italy. J Expo Anal Environ Epidemiol 14: pp. S144-S152 CrossRef
- Introduction. Book Introduction. vol. 1. pp. 900. pp. 900
- WHO report on the global tobacco epidemic: 2009 implementing smoke-free environments. World Health Organization (WHO), Geneva
- Öberg, M, Jaakkola, MS, Woodward, A, Peruga, A, Prüss-Ustün, A (2011) Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries. Lancet 377: pp. 139-146 CrossRef
- The health consequences of involuntary exposure to tobacco smoke: A report of the Surgeon General. Book The health consequences of involuntary exposure to tobacco smoke: A report of the Surgeon General. vol. 29. pp. 1–27. pp. 1-27
- Prefontaine, D, Morin, A, Jumarie, C, Porter, A (2006) In vitro bioactivity of combustion products from 12 tobacco constituents. Food Chem Toxicol 44: pp. 724-738 CrossRef
- The health consequences of smoking: the changing cigarette. A report of the Surgeon General. Book The health consequences of smoking: the changing cigarette. A report of the Surgeon General. pp. 239. pp. 239
- Bardana, EJ (2001) Indoor pollution and its impact on respiratory health. Ann Allergy Asthma Immunol 87: pp. 33-40 CrossRef
- Morawska, L, Jamriska, M, Bofinger, ND (1997) Size characteristics and ageing of the environmental tobacco smoke. Sci Total Environ 196: pp. 43-55 CrossRef
- Module 3: characteristics of particles - particle size categories ; [ http://www.epa.gov/eogapti1/bces/module3/category/category.htm]
- Richter, E, Scherer, G Aktives und passives Rauchen. In: Marquardt, H, Schäfer, S eds. (2004) Lehrbuch der Toxikologie. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgartpp. 1348
- Hoffmann, D, Hoffmann, I, El-Bayoumy, K (2001) The less harmful cigarette: a controversial issue. A tribute to Ernst L. Wynder. Chem Res Toxicol 14: pp. 767-790 CrossRef
- Marian, C, O’Connor, RJ, Djordjevic, MV, Rees, VW, Hatsukami, DK, Shields, PG (2009) Reconciling human smoking behavior and machine smoking patterns: implications for understanding smoking behavior and the impact on laboratory studies. Cancer Epidemiol Biomarkers Prev 18: pp. 3305-3320 CrossRef
- Zacny, JP, Stitzer, ML (1994) Human Smoking Patterns. Book Human Smoking Patterns. pp. 150–160. pp. 150-160
- Liu, S, Zhu, Y (2010) A case study of exposure to ultrafine particles from secondhand tobacco smoke in an automobile. Indoor Air 20: pp. 412-423 CrossRef
- Ott, W, Klepeis, N, Switzer, P (2008) Air change rates of motor vehicles and in-vehicle pollutant concentrations from secondhand smoke. J Expo Sci Environ Epidemiol 18: pp. 312-325 CrossRef
- Sohn, H, Lee, K (2010) Impact of smoking on in-vehicle fine particle exposure during driving. Atmos Environ 44: pp. 3465-3468 CrossRef
- Rees, VW, Connolly, GN (2006) Measuring air quality to protect children from secondhand smoke in cars. Am J Prev Med 31: pp. 363-368 CrossRef
- Invernizzi, G, Ruprecht, A, Mazza, R, Rossetti, E, Sasco, A, Nardini, S, Boffi, R (2004) Particulate matter from tobacco versus diesel car exhaust: an educational perspective. Tob Control 13: pp. 219-221 CrossRef
- Vardavas, CI, Linardakis, M, Kafatos, AG (2006) Environmental tobacco smoke exposure in motor vehicles: a preliminary study. Tob Control 15: pp. 415-416 CrossRef
- Witschi, H (1999) Some notes on the history of Haber’s law. Toxicol Sci 50: pp. 164-168 CrossRef
- Rozman, KK (1999) Delayed acute toxicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD), after oral administration, obeys Haber’s Rule of inhalation toxicology. Toxicol Sci 49: pp. 102-109 CrossRef
- Air Quality Guidelines for Europe.
- Reference Cigarette Program; [ http://www.ca.uky.edu/refcig/]
- Tabakerzeugnisse; [ http://service.ble.de/tabakerzeugnisse/index2.php?site_key=153&site_key=153]
- Rustemeier, K, Stabbert, R, Haussmann, HJ, Roemer, E, Carmines, EL (2002) Evaluation of the potential effects of ingredients added to cigarettes. Part 2: chemical composition of mainstream smoke. Food Chem Toxicol 40: pp. 93-104 CrossRef
- Baker, RR, da Silva, JRP, Smith, G (2004) The effect of tobacco ingredients on smoke chemistry. Part I: flavourings and additives. Food Chem Toxicol 42: pp. S3-S37 CrossRef
- Particulate matter (PM) 2.5 levels in ETS emissions of a Marlboro Red cigarette in comparison to the 3R4F reference cigarette under open- and closed-door condition
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- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Journal of Occupational Medicine and Toxicology
- Online Date
- June 2012
- Online ISSN
- BioMed Central
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- Author Affiliations
- 1. Institute of Occupational, Social and Environmental Medicine, Goethe-University, Frankfurt am Main, Germany
- 2. Office of the Dean, Goethe-University, Frankfurt am Main, Germany
- 3. Institute of Biostatistics and Mathematical Modeling, Goethe-University, Frankfurt am Main, Germany