Smoking Status and Metabolic Syndrome in the Multi-Ethnic Study of Atherosclerosis. A cross-sectional study
- Ivan BerlinAffiliated withHôpital Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris, Université P. & M. Curie, Faculté de médecine, INSERM 894 Email author
- , Susan LinAffiliated withCenter for Family and Community Medicine, Columbia University
- , Joao A C LimaAffiliated withJohns Hopkins University School of Medicine
- , Alain Gerald BertoniAffiliated withWake Forest University School of Medicine
Current smoking is associated with type 2 diabetes mellitus and impaired glucose tolerance but its association with the metabolic syndrome (metS), particularly with sufficiently sampled African American representation, has not been clearly established.
To assess whether a) metS is associated with smoking; b) any increased risk of metS among smokers is independent of body mass index (BMI) compared with non-smokers; c) smoking status is differentially associated with the metS and its components across different ethnic groups.
Cross sectional analysis of the Multi-Ethnic Study of Atherosclerosis (MESA) a community population-based sample free of cardiovascular disease.
Current smokers (N = 769) had higher risk of metS (odds ratio [OR, 95% confidence interval]: 1.4, 1.1-1.7) versus never (reference, N = 2981) and former smokers (1.0, 0.8-1.1, N = 2163) and for metS components: high waist circumference (WC) (OR:1.9, 1.2-2.1), low high density lipoprotein cholesterol (HDL-C) (1.5, 1.3-1.8), elevated plasma triglycerides (TG) (OR:1.4, 1.2-1.7) as well as high C-reactive protein (CRP, an inflammatory marker) concentration (OR: 1.6,1.3-2.0) compared to never and former smokers after adjustment for BMI. A smoking status by ethnicity interaction occurred such that African American current and former smokers had greater likelihood of low HDL-C than White counterparts.
This study found that smoking is associated with the metS and despite the lower BMI of current smokers the prevalence of low HDL-C, elevated TG and CRP is higher among them than among non-smokers. African Americans generally have higher HDL-C than Whites but smoking wipes out this advantage.
Multi-Ethnic Study of Atherosclerosis (MESA) ClinicalTrials.gov Identifier: NCT00005487
KeywordsMetabolic syndrome Smoking Ethnic groups Body mass index
- Smoking Status and Metabolic Syndrome in the Multi-Ethnic Study of Atherosclerosis. A cross-sectional study
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Tobacco Induced Diseases
- Online Date
- June 2012
- Online ISSN
- BioMed Central
- Additional Links
- Metabolic syndrome
- Ethnic groups
- Body mass index
- Author Affiliations
- 1. Hôpital Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris, Université P. & M. Curie, Faculté de médecine, INSERM 894, Paris, France
- 2. Center for Family and Community Medicine, Columbia University, New York, NY, USA
- 3. Johns Hopkins University School of Medicine, Baltimore, MD, USA
- 4. Wake Forest University School of Medicine, Winston-Salem, NC, USA