, 9:P25,
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Date: 19 Nov 2012

Dose finding of OpunDiaTM (O. ficus-indica extract) for its effect on oral glucose tolerance and plasma insulin

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Background

High-intensity exercise typically leads to a depletion of body carbohydrate stores, primarily muscle glycogen. Therefore, typical ‘sports recovery drinks’ include a high carbohydrate dose together with proteins so as to stimulate muscle glucose uptake and glycogen resynthesis via increased plasma insulin level. In fact, any intervention that elevate plasma insulin following exercise could facilitate repletion of muscle glycogen stores, and serve as a useful ‘recovery agent’. Extracts of the prickly pear cactus (Opuntia ficus-indica; OFI) can stimulate insulin secretion [1], but the most effective dose was not yet elucidated.

Methods

A double-blind randomized cross-over study was performed. Five subjects participated in four experimental sessions after a 10-12 hr overnight fast with a 1-week interval in between. They received either 500, 1000 or 1500 mg of encapsulated OFI-extract (OpunDiaTM, an aqueous extract of OFI; Finzelberg GmbH & Co. KG, Germany), or placebo capsules (LUV